ESTRO 2024 - Abstract Book

S4997

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Conclusion:

Regions of combined high dose and LETd showed a positive association with necrotic voxels in this cohort. The mixed effect model considering patient heterogeneity best described the association.

Keywords: Variable RBE, Voxel Analysis, Brainstem Necrosis

References:

[1] Underwood TSA, McNamara AL, Appelt A, et al. A systematic review of clinical studies on variable proton Relative Biological Effectiveness (RBE). Radiother Oncol 2022; 175: 79-92. https://doi.org/10.1016/j.radonc.2022.08.014

[2] Bates D, Mächler M, Bolker B, et al. Fitting Linear Mixed-Effects Models Using lme4. Journal of Statistical Software 2015; 67: 1 - 48. https://doi.org/10.18637/jss.v067.i01