ESTRO 2024 - Abstract Book

S5002

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Conclusion:

In conclusion, high-risk subvolumes, calculated by a band of ADC values, show small intrafractional volume changes, but volume congruence was weak, depending on the absolute volume, demonstrated by small DSC and medium distances of COMs. With the application of filtering volume congruence was increased, indicating that these HRSs are often located in small GTVs and spread across the GTV. In respect thereof, adequate treatment planning strategies for biology-guided RT have to be implemented before ADC-based dose escalation can be realized in the future.

Funding: DFG (PAK 997/1: TH 1528/6-1 and ZI 736/2-1). COI: research collaborations Elekta AB, Philips, PTW Freiburg, Dr. Sennewald Medizintechnik, Kaiku Health, TheraPanacea, ITV.

Keywords: ADC, MR-Linac, Quantitative imaging biomarker

References:

[1] Lambrecht M, Van Calster B, Vandecaveye V, De Keyzer F, Roebben I, Hermans R, et al. Integrating pretreatment diffusion weighted MRI into a multivariable prognostic model for head and neck squamous cell carcinoma. Radiother Oncol. 2014;110:429-34.