ESTRO 2024 - Abstract Book

S5057

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

1. Kruser TJ, McCabe BP, Mehta MP, et al. Reirradiation for locoregionally recurrent lung cancer: outcomes in small cell and non-small cell lung carcinoma. Am J Clin Oncol 2014;37:70-6.

2. Hong JH, Kim Y-S, Lee S-W, et al. High-dose thoracic re-irradiation of lung cancer using highly conformal radiotherapy is effective with acceptable toxicity. Cancer research and treatment: official journal of Korean Cancer Association 2019;51:1156. 3. Bradley JD, Paulus R, Komaki R, et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncology 2015;16:187-99.

4. Guyot P, Ades AE, Ouwens MJ, Welton NJ. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol 2012;12:9.

1512

Digital Poster

multi-modality prediction of radiation induced hypothyroidism for nasopharyngeal carcinoma patients

Jiaming Wu 1 , Jiang Zhang 1 , Xinzhi Teng 1 , Xinyu Zhang 1 , Jiachen Sun 1 , Ka Man Cheung 2 , C.F. Jeffrey Lui 2 , W.Y.Celia Yip 2 , K.H.Francis Lee 2 , C.H.James Chow 2 , Jing Cai 1,3,4 1 The Hong Kong Polytechnic University, Department of Health Technology and Informatics, Hong Kong SAR, China. 2 Queen Elizabeth Hospital, Department of Clinical Oncology, Hong Kong SAR, China. 3 The Hong Kong Polytechnic University, Research Institute for Smart Ageing, Hong Kong SAR, China. 4 The Hong Kong Polytechnic University Shenzhen Research Institute, The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China

Purpose/Objective:

We plan to investigate the predictive performance of the multi-model radiotherapy data on the occurrence of radiation-induced hypothyroidism (RIHT) after intensity modulated radiotherapy (IMRT) for patients with nasopharyngeal carcinoma (NPC).

Material/Methods:

A total of 428 NPC patients were retrospectively recruited from a tertiary oncology center, and the computer tomography (CT) images, planning dose distributions, and clinical records were collected. The thyroid volumes were manually delineated by experienced oncologists. We calculated a comprehensive set of dosiomics and radiomics features in the thyroid regions of the CT images and dose maps after preprocessing using the pyradiomics package in Python. High-repeatable features were selected using the perturbation method[1], and the Mann-Whitney U test was used to select features with statistically significant associations with RIHT. The features satisfied the intraclass correlation coefficient > 0.9 during perturbation and p-value<0.05 in the Mann-Whitney U test were considered as having excellent repeatability and statistically significant. The mRMR (minimum Redundancy Maximum Relevance)