ESTRO 2024 - Abstract Book

S5073

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Figure 1. Boxplots of the ADC of the conventional DWI model and D of the NG-IVIM DWI model; white boxplot depicts parameter values for the HPV negative patients with a complete response (CR) and the grey boxplot for the HPV negative patients with progressive disease (PD). The horizontal line represents the median, the boxes the 25 th to 75 th percentile and error bars represent the 5 th to 95 th percentile.

Conclusion:

While in current literature, both HPV negative status and higher extracellular diffusion in terms of ADC are correlated to poorer response, in our cohort of HPV negative patients, we found that only a lower extracellular diffusion in terms of D was related to poorer response. Moreover, the correlation was in the opposite direction as expected based on previous literature that did not correct for HPV status. These findings suggest that ADC is indeed a surrogate for HPV status instead of an independent response predictor, and highlights the need of applying NG-IVIM DWI instead of conventional ADC DWI for response prediction.

Keywords: Diffusion Weighted Imaging, Response, OPSCC

References:

[1] Sijtsema (2020) Radiotherapy and Oncology

[2] Sijtsema (2021) proffered paper ESTRO conference

[3] Chawla (2013) AJR Am J Roentgenol

[4] Freihat (2021) Oral Oncol