ESTRO 2024 - Abstract Book

S5090

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

The study is supported by the AIRC grant IG 25951.

[1] Mori M, Passoni P, Incerti E, et al. Training and validation of a robust PET radiomic-based index to predict distant relapse-free-survival after radio-chemotherapy for locally advanced pancreatic cancer. Radiother Oncol. 2020;153:258-264. doi:10.1016/j.radonc.2020.07.003

[2] Whybra, P., Parkinson, C., Foley, K. et al. Assessing radiomic feature robustness to interpolation in 18F-FDG PET imaging. Sci Rep 9, 9649 (2019). https://doi.org/10.1038/s41598-019-46030-0

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Digital Poster

Apparent diffusion coefficient maps as early biomarker for carbon ion RT in adenoid cystic carcinoma

Giulia Fontana 1 , Maria Bonora 1 , Antonella Donatelli 2 , Barbara Vischioni 1 , Sara Ronchi 1 , Rossana Ingargiola 1 , Anna Maria Camarda 1 , Sara Lillo 1 , Silvia Molinelli 1 , Stefania Russo 1 , Viviana Vitolo 1 , Maria Rosaria Fiore 1 , Alberto Iannalfi 1 , Amelia Barcellini 1,3 , Giulia Riva 1 , Lucia P Ciccone 1 , Agnieszka Chalaszczyk 1 , Marco Rotondi 1 , Jessica Franzetti 1 , Francesca Colombo 1 , Mario Ciocca 1 , Lorenzo Preda 2,4 , Sara Imparato 1 , Ester Orlandi 1 1 National Center for Oncological Hadrontherapy (CNAO), Clinical Department, Pavia, Italy. 2 University of Pavia, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Pavia, Italy. 3 University of Pavia, Department of Internal Medicine and Medical Therapy, Pavia, Italy. 4 IRCCS Fondazione Policlinico San Matteo, Division of Radiology, Pavia, Italy

Purpose/Objective:

To evaluate the role of the apparent diffusion coefficient (ADC) maps derived from diffusion-weighted magnetic resonance imaging (DW-MRI) as early biomarker for local relapse free survival (LRFS) in adenoid cystic carcinomas (ACC) patients treated with Carbon Ion Radiotherapy (CIRT).

Material/Methods:

Retrospective clinical and radiological data were collected for ACC patients treated with curative CIRT at our institution between March 2013 and July 2021, and having at least 2-years of follow-up. Only patients with histological diagnosis of ACC and no previous surgery at the treatment site were included in the present study. Our analysis evaluated DW MRI performed at baseline and after 6-months follow-up on a 3 Tesla MR scanner at our institution, while external follow-up MRI exams were not evaluated for imaging consistency purposes. MRI protocols included at least the following sequences: T2-weighted Turbo Spin-Echo (T2-w TSE) acquired in axial plane; T2-w TSE with inversion recovery fat suppression technique (STIR) in axial, sagittal and coronal planes; two-dimensional single shot echo planar imaging (EP2D) DW-MRI acquired in axial plane (including at least b-values= 50, 400, 1000 [s/mm2]); T1 weighted volumetric interpolated breath-hold examination post contrast injection (T1-w vibe). An experienced radiologist manually contoured the lesions on the baseline and 6-months follow-up DW-MRI, aided by the previously mentioned sequences (Figure 1). Hence, first-order imaging histogram features were extracted for the ADC