ESTRO 2024 - Abstract Book

S5098

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Conclusion:

We developed a hypoxia detection protocol for use on both a diagnostic MR and MRL which will be validated on its concordance with pimonidazole and GLUT1 staining in prostate cancer. To facilitate accurate co-registration, MR sequences were acquired in the expected plane of histological dissection using 3D-printed prostate moulds following a methodology shown to improve the accuracy of registering histology to imaging. [3] trans in DIL than NP which is consistent with previously published literature.[5,6] This study will be the first comparison of OE-MR in prostate cancer against a histological marker of tumour hypoxia. BOLD and IVIM sequences acquired on a diagnostic MR have been previously validated in prostate cancer against pimonidazole-stained specimens [7,8] but not previously investigated on the MR Linac. We observed lower D, lower v e and higher k

Keywords: Hypoxia,Prostate,MRLinac

References:

1, Lalonde E, Ishkanian AS, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning MJ, Halim S, Lamb AD, Moon NC, Zafarana G, Warren AY, Meng X, Thoms J, Grzadkowski MR, Berlin A, Have CL, Ramnarine VR, Yao CQ, Malloff CA, Lam LL, Xie H, Harding NJ, Mak DYF, Chu KC, Chong LC, Sendorek DH, P'ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC, Bristow RG. Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study. Lancet Oncol. 2014 Dec;15(13):1521-1532. doi: 10.1016/S1470 2045(14)71021-6. Epub 2014 Nov 13. PMID: 25456371. 2, Milosevic M, Warde P, Ménard C, Chung P, Toi A, Ishkanian A, McLean M, Pintilie M, Sykes J, Gospodarowicz M, Catton C, Hill RP, Bristow R. Tumor hypoxia predicts biochemical failure following radiotherapy for clinically localized prostate cancer. Clin Cancer Res. 2012 Apr 1;18(7):2108-14. doi: 10.1158/1078-0432.CCR-11-2711. Epub 2012 Mar 31. PMID: 22465832. 3, F. Commandeur et al., "Prostate whole-mount histology reconstruction and registration to MRI for correlating in vivo observations with biological findings," 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy, 2015, pp. 2399-2402, doi: 10.1109/EMBC.2015.7318877. 4, Ram S, Vizcarra P, Whalen P, Deng S, Painter CL, Jackson-Fisher A, Pirie-Shepherd S, Xia X, Powell EL. Pixelwise H score: A novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images. PLoS One. 2021 Sep 27;16(9):e0245638. doi: 10.1371/journal.pone.0245638. PMID: 34570796; PMCID: PMC8475990. 5, Tamada, T., Sone, T., Jo, Y., Toshimitsu, S., Yamashita, T., Yamamoto, A., Tanimoto, D. and Ito, K. (2008), Apparent diffusion coefficient values in peripheral and transition zones of the prostate: Comparison between normal and malignant prostatic tissues and correlation with histologic grade. J. Magn. Reson. Imaging, 28: 720-726. https://doi.org/10.1002/jmri.21503