ESTRO 2024 - Abstract Book

S5102

Physics - Radiomics, functional and biological imaging and outcome prediction

ESTRO 2024

Figure 1 . Cox-based NTCP model for grade 5 bleeding at 1, 2, 3, 4, and 5 years after SBRT treatment including D 0.31cc for the main and intermediate bronchi and tracheobronchial compression. Solid lines are without tracheobronchial compression and dashed lines are with tracheobronchial compression. Blue dots are D 0.31cc for patients without tracheobronchial compression, and red diamonds are D 0.31cc for patients with tracheobronchial compression.

Conclusion:

Dose to a small volume of the main and intermediate bronchi and tracheobronchial compression are important predictors for grade 5 bleeding. For patients with ultra-central lung tumors, this provides some guidance on how to limit the risk of fatal toxicity.

Keywords: NTCP, ultra-central, bronchial dose

References:

1. Haseltine JM, Rimner A, Gelblum DY, Modh A, Rosenzweig KE, Jackson A, et al. Fatal complications after stereotactic body radiation therapy for central lung tumors abutting the proximal bronchial tree. Pract Radiat Oncol. 2016;6(2):e27-33. Tekatli H, Haasbeek N, Dahele M, De Haan P, Verbakel W, Bongers E, et al. Outcomes of Hypofractionated High-Dose Radiotherapy in Poor-Risk Patients with "Ultracentral" Non-Small Cell Lung Cancer. J Thorac Oncol. 2016;11(7):1081-9. 2.

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