ESTRO 2024 - Abstract Book

S5200

Radiobiology - Microenvironment

ESTRO 2024

Conclusion:

Phosphorylated STAT3 is highly expressed in the microglia and reactive astrocytes pertaining to the areas of brain RN. Targeting STAT3 via inhibition represents a promising strategy to ameliorate symptomatic RN in BMs patients undergoing SRS. Future studies should focus on evaluating the role of STAT3 inhibitors that cross the BBB to validate their potential as a therapeutic target.

Keywords: radiation necrosis, phosphoSTAT3, radiosurgery

References:

Xia, T.; Zhang, M.; Lei,W.; Yang, R.; Fu, S.; Fan, Z.; Yang, Y.; Zhang, T. Advances in the Role of STAT3 in Macrophage Polarization. Front. Immunol. 2023, 14, 1160719.

Priego, N.; Zhu, L.; Monteiro, C.; Mulders, M.; Wasilewski, D.; Bindeman, W.; Doglio, L.; Martínez, L.; Martínez-Saez, E.; Ramón, Y.; et al. STAT3 Labels a Subpopulation of Reactive Astrocytes Required for Brain Metastasis. Nat. Med. 2018, 24, 1024–1035. Sarmiento Soto, M.; Larkin, J.R.; Martin, C.; Khrapitchev, A.A.; Maczka, M.; Economopoulos, V.; Scott, H.; Escartin, C.; Bonvento, G.; Serres, S.; et al. STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction. Cancer Res. 2020, 80, 5642–5655. Devan, S.P.; Luo, G.; Jiang, X.; Xie, J.; Dean, D.; Johnson, L.S.; Morales-Paliza, M.; Harmsen, H.; Xu, J.; Kirschner, A.N. Rodent. Model of Brain Radionecrosis Using Clinical LINAC-Based Stereotactic Radiosurgery. Adv. Radiat. Oncol. 2022

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Poster Discussion

Targeting C5aR1 to improve radiotherapy in tumours with immunosuppressive microenvironments

Callum Beach 1 , David MacLean 1 , Dominika Majorova 1 , Gabriel N Valbuena 2 , Mahnaz Darvish Damavandi 3 , Tatsuya Suwa 1 , Alistair Easton 1 , Lily VS Hillson 4 , Ashley K McCulloch 4 , Ross K McMahon 4 , Kathryn Pennel 4 , Joanne Edwards 4 , Sean M O’Cathail 4 , Campbell S Roxburgh 4 , Eui Jung Moon 1 , Silvia Guglietta 5,6 , Carsten Krieg 6,7 , Trent M Woodruff 8 , Tim Maughan 1 , Simon JA Buczacki 3 , Simon J Leedham 2 , Amato J Giaccia 1,9 , Heather Clark 1 , Monica M Olcina 1 1 University of Oxford, Department of Oncology, Oxford, United Kingdom. 2 University of Oxford, Wellcome Centre for Human Genetics, Oxford, United Kingdom. 3 University of Oxford, Nuffield Department of Surgical Sciences, Oxford, United Kingdom. 4 University of Glasgow, School of Cancer Sciences, Glasgow, United Kingdom. 5 Medical University of South Carolina, Department of Regenerative Medicine and Cell Biology, Charleston, USA. 6 Medical University of South Carolina, Hollings Cancer Center, Charleston, USA. 7 Medical University of South Carolina, Department of Pathology and Laboratory Medicine, Charleston, USA. 8 The University of Queensland, School of Biomedical Sciences, Brisbane, Australia. 9 Stanford University, Department of Radiation Oncology, Stanford, USA