ESTRO 2024 - Abstract Book

S5212

Radiobiology - Microenvironment

ESTRO 2024

Table 2 showcases preliminary TGT3 values and corresponding P-values for different treatments groups of animals. 90 days in the table indicates animals with tumor control or without TGT3. Acute toxicity assessments studies using the above mentioned treatment conditions will reveal damage levels based on specific treatment conditions. Non-linear regression will determine optimal radiation doses for desired response and minimal toxicity (MD50 values)

Conclusion:

The synergy between radiation and heat is most effective at higher temperatures and shorter intervals based on preliminary results. Acute toxicity studies will reveal the toxicity profiles linked to various combinations of fractionated SBRT and heat, comparing them to their anti-tumor effects.

Keywords: SBRT, Hyperthermia, Hypoxia

References:

1. Song CW, Cho LC, Yuan J, Dusenbery KE, Griffin RJ, Levitt SH. Radiobiology of stereotactic body radiation therapy/stereotactic radiosurgery and the linear-quadratic model. Int J Radiat Oncol Biol Phys. 2013;87:18–19.

2. Oei et al., 2020. Molecular and biological rationale of hyperthermia as radio- and chemosensitizer A.L. Oei et al. / Advanced Drug Delivery Reviews 163–164 (2020) 84–97