ESTRO 2024 - Abstract Book

S5223

Radiobiology - Microenvironment

ESTRO 2024

Conclusion:

In conclusion, RIS vascular niches are co-opting the pro-tumoral microenvironment, in favor of highly aggressive surviving tumor cells after radiotherapy. Targeting those RIS vascular niches with new senotherapies opens new avenues to propose an innovative strategy limiting deadly GBM recurrence.

Keywords: Senescence, genomic instability, endothelium

References:

(1) Stupp, R. et al. Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma. N. Engl. J. Med. 352, 987–996 (2005).

(2) Todorova, P. K. et al. Radiation-Induced DNA Damage Cooperates with Heterozygosity of 562 TP53 and PTEN to Generate High-Grade Gliomas. Cancer Res 79, 3749–3761 (2019).

(3) Gupta, K. & Burns, T. C. Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications. Front. Oncol. 8, 503 (2018).

(4) Hernandez-Segura, A., Nehme, J. & Demaria, M. Hallmarks of Cellular Senescence. Trends Cell Biol 28, 436– 453 (2018).

(5) De Pascalis I. et al. Endothelial trans-differentiation in glioblastoma recurring after radiotherapy. Mod Pathol. 31(9):1361–6 (2018).

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Poster Discussion

Microvasculature-on-chip as radiobiological model for inflammatory response to ionizing irradiation

Luca Possenti 1 , Dalila Petta 2 , Tommaso Giandini 3 , Valentina Doldi 4 , Alessandro Cicchetti 1 , Simone Bersini 2,5 , Chiara Arrigoni 2,5 , Nadia Zaffaroni 4 , Matteo Moretti 2,5,6 , Tiziana Rancati 1 1 Fondazione IRCCS Istituto Nazionale dei Tumori, Data Science Unit, Milan, Italy. 2 Ente Ospedaliero Cantonale, Regenerative Medicine Technologies Lab, Service of Orthopaedics and Traumatology, Bellinzona, Switzerland. 3 Fondazione IRCCS Istituto Nazionale dei Tumori, Medical Physics Unit, Milan, Italy. 4 Fondazione IRCCS Istituto Nazionale dei Tumori, Molecular Pharmacology Unit, Milan, Italy. 5 Università della Svizzera Italiana (USI), Euler Institute, Biomedical Sciences Faculty, Lugano, Switzerland. 6 IRCCS Istituto Ortopedico Galeazzi, Cell and Tissue Engineering Laboratory, Milan, Italy

Purpose/Objective: