ESTRO 2024 - Abstract Book

S5254 ESTRO 2024 decrease in micturition of 3.1-fold (p value < 0.0001) compared with irradiated untreated rats. At histological level we observed an increase in the number of mast cells (fold change=1.5±0.56; p value <0,05) in irradiated untreated rats compared with untreated unirradiated rats. The number of mast cells is not significantly different from the 2 groups of irradiated rats (MSC treated or not).[5] Radiobiology - Normal tissue radiobiology

Conclusion:

Preclinical modeling of radiation-induced cystitis in rats enables us to both study the underlying mechanisms and to test therapeutic strategies. Our results show that MSC could limit the progression of the chronic phase of radiation-induced cystitis. The treatment with MSC would allow to rebalance the tissue homeostasis by promoting differentiation of superficial cell. This MSC treatment may offer an alternative for patients suffering from chronic radiation cystitis resistant to conventional treatments.

Keywords: Radiation cystitis, Mesenchymal stromal cell

References:

1. Song, M., et al., Mesenchymal Stem Cell Therapy Alleviates Interstitial Cystitis by Activating Wnt Signaling Pathway. Stem Cells Dev, 2015. 24(14): p. 1648-57.

2. Voswinkel, J., et al., Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: a comprehensive review. Clin Rev Allergy Immunol, 2013. 45(2): p. 180-92.

3. Aronsson-Kurttila, W., et al., Placenta-Derived Decidua Stromal Cells for Hemorrhagic Cystitis after Stem Cell Transplantation. Acta Haematol, 2018. 139(2): p. 106-114.

4. Ringden, O., et al., Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon. Leukemia, 2007. 21(11): p. 2271-6.

5.

Brossard, C., et al., Mesenchymal stem cells limit vascular and epithelial damage and restore the

impermeability of the urothelium in chronic radiation cystitis. Stem Cell Res Ther, 2023. 14(1): p. 5.

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Proffered Paper

Reducing inflammatory and cognitive effects of irradiation in healthy brain using PARP inhibitors

Duncan M Forster 1 , Jennifer Fletcher 2 , Mark Jackson 3 , Rodrigo Gutierrez Quintana 3 , Karin Williams 3 , Anthony Chalmers 3 , Kaye Williams 2 1 University of Manchester, Division of Informatics, Imaging and Data Sciences, Manchester, United Kingdom. 2 University of Manchester, Faculty of Biology, Medicine and Health, Manchester, United Kingdom. 3 University of Glasgow, Institute of Cancer Sciences, Glasgow, United Kingdom

Purpose/Objective: