ESTRO 2024 - Abstract Book

S5266 ESTRO 2024 1. Carmen Bergom, Julie A. Bradley, Andrea K. Ng, Pamela Samson, Clifford Robinson, Juan Lopez-Mattei, Joshua D. Mitchell. Past, Present, and Future of Radiation-Induced Cardiotoxicity: Refinements in Targeting, Surveillance, and Risk Stratification, JACC: CardioOncology, Volume 3, Issue 3, 2021, Pages 343-359, ISSN 2666-0873, https://doi.org/10.1016/j.jaccao.2021.06.007. 2. McWilliam A, Khalifa J, Vasquez Osorio E, Banfill K, Abravan A, Faivre-Finn C, van Herk M. Novel Methodology to Investigate the Effect of Radiation Dose to Heart Substructures on Overall Survival. Int J Radiat Oncol Biol Phys. 2020 Nov 15;108(4):1073-1081. doi: 10.1016/j.ijrobp.2020.06.031. Epub 2020 Jun 23. PMID: 32585334. 3. Ghita M, Gill EK, Walls GM, Edgar KS, McMahon SJ, Osorio EV, Bergom C, Grieve DJ, Watson CJ, McWilliam A, Aznar M, van Herk M, Williams KJ, Butterworth KT. Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart. Radiother Oncol. 2020 Nov;152:216-221. doi: 10.1016/j.radonc.2020.07.016. Epub 2020 Jul 12. PMID: 32663535; PMCID: PMC10181791. Radiobiology - Normal tissue radiobiology

4. Mohammed, T., Singh, M., Tiu, J.G. et al. Etiology and management of hypertension in patients with cancer. Cardio-Oncology 7, 14 (2021). https://doi.org/10.1186/s40959-021-00101-2

5. Little R, Zi M, Hammad SK, Nguyen L, Njegic A, Kurusamy S, Prehar S, Armesilla AL, Neyses L, Austin C, Cartwright EJ. Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries. Aging Cell. 2017 Oct;16(5):1104-1113. doi: 10.1111/acel.12637. Epub 2017 Aug 9. PMID: 28795531; PMCID: PMC5595685.

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Digital Poster

Genetic Biomarkers of Radiotherapy-Associated Toxicities in Head and Neck Cancer Patients

Philipp Reinhardt 1 , Ursula Amstutz 2 , Andrej Benjak 3 , Olgun Elicin 1 , Matúš Medo 3 , Roland Giger 4 , Michaela Medová 3 , Charlotte Ng 3 , Yitzhak Zimmer 3 , Daniel M Aebersold 1 , Daniel H Schanne 1,5 1 Inselspital, Bern University Hospital and University of Bern, Department of Radiation Oncology, Bern, Switzerland. 2 Inselspital, Bern University Hospital and University of Bern, Clinical Genomics Lab, Bern, Switzerland. 3 University of Bern, Department for BioMedical Research, Bern, Switzerland. 4 Inselspital, Bern University Hospital and University of Bern, Department of Otorhinolaryngology, Bern, Switzerland. 5 University of Bern, Graduate School for Health Sciences, Bern, Switzerland

Purpose/Objective:

Radiotherapy (RT) is fundamental in treating head and neck squamous cell carcinoma (HNSCC) but acute and long term toxicity can cause significant treatment complications and impair patients’ quality of life. Identifying reliable biomarkers to predict toxicity is a crucial precondition to develop a more individualized approach to RT and supportive therapy. Inter-individual genetic alterations may be suitable to develop predictive models of RT-related toxicity and could therefore serve as the basis for personalized treatment. This retrospective study was designed to analyze associations of genetic alterations, identified by whole-exome sequencing, with clinically evaluated toxicity during and after RT for HNSCC.

Material/Methods: