ESTRO 2024 - Abstract Book

S1047

Clinical - Gynaecology

ESTRO 2024

3. Portman DJ, Gass ML; Vulvovaginal Atrophy Terminology Consensus Conference Panel. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and the North American Menopause Society. Maturitas. 2014 Nov;79(3):349-54. doi: 10.1016/j.maturitas.2014.07.013. Epub 2014 Aug 19. PMID: 25179577. 4. Suvaal I, Kirchheiner K, Nout RA, Sturdza AE, Van Limbergen E, Lindegaard JC, et al. Vaginal changes, sexual functioning and distress of women with locally advanced cervical cancer treated in the EMBRACE vaginal morbidity substudy. Gynecol Oncol. 2023 Mar;170:123-132. doi: 10.1016/j.ygyno.2023.01.005. Epub 2023 Jan 20. PMID: 36682090.

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Digital Poster

Dynamic evaluation of 18F-FDG-PET SUVmax and inflammatory indices in cervical cancer patients

Federica Medici 1,2 , Ludovica Forlani 1,2 , Viola Laghi 1,2 , Johnny Ma 1,2 , Gabriella Macchia 3 , Francesco Deodato 3,4 , Anna Myriam Perrone 1,5 , Claudio Malizia 6 , Paolo Castellucci 6 , Stefano Fanti 1,6 , Valentino Dragonetti 1,6 , Lorenzo Spagnoli 7 , Giuseppe Della Gala 7 , Martina Ferioli 1 , Silvia Cammelli 1,2 , Alessio Giuseppe Morganti 1,2 1 Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 2 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 3 Radiation Oncology Unit, Gemelli Molise Hospital - Università Cattolica del Sacro Cuore, Campobasso, Italy. 4 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy. 5 Oncologic Gynaecology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 6 Nuclear Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 7 Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Purpose/Objective:

This study aimed to assess the predictive value of changes in 18-F-FDG-PET Δ-SUVmax (the difference in tumor SUVmax before and after treatment) and a variety of systemic inflammatory markers (changes from pre- to post treatment) in a large group of patients with locally advanced cervical cancer (LACC) who received concurrent chemoradiation (CRT) plus brachytherapy boost.

Material/Methods:

The study analyzed LACC patients treated at our institution between 2007 and 2021. Patients underwent definitive CRT, and their pre- and post-treatment measurements included 18-F-FDG-PET tumor SUVmax, prognostic nutritional index, and various inflammatory markers (e.g., neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, etc.). Changes (Δ) in these values were calculated. The correlations between these changes, clinical parameters (e.g., age, hemoglobin level, BMI), tumor characteristics (e.g., FIGO stage, tumor diameter), treatment details (e.g., dose, fractionation, technique, overall treatment time), and local control (LC), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed using univariate and multivariate Cox regression.