ESTRO 2024 - Abstract Book

S1048

Clinical - Gynaecology

ESTRO 2024

Results:

A total of 173 patients were included in the study. In univariate analysis, changes in inflammatory markers were not significantly associated with outcomes. However, higher Δ-SUVmax was correlated with improved LC (p=0.001), DFS (p=0.030), and OS (p=0.010). In multivariable analysis, factors significantly associated with outcomes included higher hemoglobin levels (as a continuous variable) and 18-F-FDG-PET Δ-SUVmax ≥12.35 for DFS. Factors linked to better OS included higher hemoglobin levels, 18-F-FDG-PET Δ-SUVmax ≥12.35, less advanced tumors not requiring extended nodal irradiation, and Δ-aspartate aminotransferase to neutrophil ratio index (ANRI) ≥3.56.

Conclusion:

This analysis indicates that in LACC patients, prognosis can be accurately predicted by assessing changes in SUV and ANRI before and after treatment, in addition to traditional patient and treatment-related factors.

Keywords: Δ-FDG-PET-SUVmax, inflammatory indices, cervical

1928

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Federica Medici 1,2 , Milly Buwenge 1 , Ludovica Forlani 1,2 , Viola Laghi 1,2 , Johnny Ma 1,2 , Gabriella Macchia 3 , Francesco Deodato 3,4 , Savino Cilla 5 , Anna Myriam Perrone 1,6 , Pierandrea De Iaco 1,6 , Alessandra Arcelli 2 , Silvia Cammelli 1,2 , Alessio Giuseppe Morganti 1,2 , Martina Ferioli 1 1 Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy. 2 Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. 3 Radiation Oncology Unit, Gemelli Molise Hospital - Università Cattolica del Sacro Cuore, Campobasso, Italy. 4 Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy. 5 Medical Physics Unit, Gemelli Molise Hospital - Università Cattolica del Sacro Cuore, Campobasso, Italy. 6 Oncologic Gynaecology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy