ESTRO 2024 - Abstract Book

S1049

Clinical - Gynaecology

ESTRO 2024

Purpose/Objective:

Social and demographic disparities in cancer survival have been widely studied, but such evidence for cancer patients in Italy is limited, despite significant immigration over the past few decades. This preliminary study aims to investigate potential disparities in stage and outcomes among patients with locally advanced cervical cancer (LACC) who underwent chemoradiation plus brachytherapy boost, comparing patients of Italian and foreign origin.

Material/Methods:

Data were extracted from a single-center observational study on LACC (FIGO IB-IVA). The study examined age, BMI, FIGO stage, tumor diameter, local control (LC), disease-free survival (DFS), and overall survival (OS). These parameters were compared between Western European (including Italian) patients and those of different geographical origins.

Results:

A total of 173 LACC patients were included: 132 were Western European (including Italian), 30 Eastern European, 6 African, 3 South American, and 2 Asian. The results, as shown in Table 1, indicate a significantly younger median age in patients of different geographical origins compared to Western European patients (49 vs. 58 years; p<.001). However, there were no significant differences in terms of BMI, FIGO stage, tumor diameter, or outcomes, including LC, DFS, and OS.

Conclusion:

This analysis revealed no significant disparities in tumor size, stage at diagnosis, or survival outcomes between Western European patients and those of different geographical origins. It's important to note that this finding is limited to patients who accessed the Italian national health service. Moreover, the unexpectedly low representation of Asian LACC patients in the study may be a result of specific demographic patterns in the study region, which has a substantial population of Bengali, Filipino, and Chinese residents.

Keywords: social disparities, cervical cancer, survival