ESTRO 2024 - Abstract Book

S1050

Clinical - Gynaecology

ESTRO 2024

1982

Digital Poster

LADIES Project: Large Database In Endometrial cancers for a personalized treatment

Raffaella Michela Rinaldi 1 , Rosa Autorino 1 , Andrea Vavassori 2 , Gabriella Macchia 3 , Mariangela Boccardi 3 , Inga Mihoci Roshanian 4 , Bianca Santo 5 , Martina Ferioli 6 , Elisabetta Perrucci 7 , Arcangela Raguso 8 , Paolo Matteucci 9 , Lorena Draghini 10 , Antonietta Augurio 11 , Paola Cocuzza 12 , Lisa Vicenzi 13 , Francesca Pistis 14 , Francesca De Felice 15 , Sofia Meregalli 16 , Maria Tamburo 17 , Maria Antonietta Gambacorta 1 , Cynthia Aristei 7 1 Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC Radioterapia Oncologica, Roma, Italy. 2 Istituto Europeo di Oncologia, Radioterapia, Milano, Italy. 3 Gemelli Molise, Radiation Oncology Unit, Campobasso, Italy. 4 Ospedale L’Aquila, U.O.S.D Radioterapia e Cardioradiologia, L'Aquila, Italy. 5 Ospedale Vito Fazzi, U.O. Radioterapia Oncologica, Lecce, Italy. 6 Alma Mater Studiorum-Bologna University, Department of Experimental, diagnostic and speciality Medicine-DIMES, Bologna, Italy. 7 University of Perugia and Perugia General Hospital, Radiation Oncology Section, Department of Medicine and Surgery, Perugia, Italy. 8 Fondazione Casa Sollievo della Sofferenza IRCCS, Servizio di Radioterapia Oncologica, San Giovanni Rotondo, Italy. 9 Campus Biomedico, . Radioterapia Oncologica, Roma, Italy. 10 Az. Ospedaliera S. Maria, S.C. Radioterapia Oncologica, Terni, Italy. 11 Ospedale Santissima Annunziata, Radioterapia Oncologica, Chieti, Italy. 12 S. Luca Hospital, Healthcare Company Tuscany Nord Ovest, Radiation Oncology Unit, Lucca, Italy. 13 Azienda Ospedaliero Universitaria Ospedali Riuniti, Radiation Oncology Unit, Ancona, Italy. 14 PO “A. Businco” ARNAS Brotzu, SC Radioterapia, Cagliari, Italy. 15 Policlinico Umberto I “Sapienza” University of Rome, Department of Radiotherapy, Roma, Italy. 16 Monza -RT -San Gerardo, . Department of Radiotherapy, Monza, Italy. 17 Azienda Ospedaliera, Cannizzaro, Department of Radiotherapy, Catania, Italy

Purpose/Objective:

To evaluate the role of radiotherapy for endometrial cancer in a retrospective multicentric Italian study.

Material/Methods:

A large database derived from 16 Italian Radiation Oncology Centres was built. Patients treated between 2010 and 2020 with surgery, post-operative external beam radiotherapy and/or interventional radiotherapy preceded or not by adjuvant chemotherapy were analysed. They were classified on the basis of the standard risk factors (Concin et al., 2021), merging the intermediate and high-intermediate risk classes into one intermediate group and including advanced and metastatic risk group in high risk level. In this way we divided the patients into three risk groups: low, intermediate and high. We correlated outcomes (local relapse, distant metastasis, overall survival and cancer specific survival) and acute and late toxicity with treatments type and risk levels.

Results:

A total of 1848 patients (median age 65 years, range 27-88 years) were analysed.