ESTRO 2024 - Abstract Book

S1411

Clinical - Head & neck

ESTRO 2024

(3) Burtness B, Harrington KJ, Greil R, et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 2019 Nov 23;394(10212):1915-1928. (4) Nutting C, Finneran L, Roe J, et al. Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): a phase 3, multicentre, randomised, controlled trial. Lancet Oncol 2023 Aug;24(8):868-880. (5) Kuhs KAL, Brenner JC, Holsinger FC, et al. Circulating Tumor HPV DNA for Surveillance of HPV-Positive Oropharyngeal Squamous Cell Carcinoma: A Narrative Review. JAMA Oncol. 2023 Oct 12.doi: 10.1001/jamaoncol.2023.4042. (6) Warlow SJ, Adamowicz M, Thompson JP, et al. Longitudinal measurement of HPV copy number in cell-free DNA is associated with patient outcomes in HPV-positive oropharyngeal cancer. Eur J Surg Oncol2022 Jun;48(6):1224 1234. (7) Mehanna H, Sen M, Chester JD, et al. Phase III randomised controlled trial (RCT) comparing alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer (CompARE). Journal of Clinical Oncology 2017 35:15_suppl, TPS6091.

2514

Digital Poster

Correlation between oral mucositis and oncological outcomes in HNC patients: a prospective study

Elsa Beatriz Monroy-Ordonez, Andreas Thomsen, Michael Henke, Raluca Stoian, Henning Schäfer, Anca-Ligia Grosu, Tanja Sprave

Medical Center, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK) partner site Freiburg, Department of Radiation Oncology, Freiburg, Germany

Purpose/Objective:

For advanced head and neck squamous cell carcinomas, radio(chemo)therapy is an integral part of the curative treatment. Mucositis is the most frequent side effect of radiotherapy. In this prospective study, the vulnerability of the oral mucosa to irradiation was clinically objectified and correlated with oncologic endpoints.

Material/Methods:

Eighty-four patients treated with primary or adjuvant radio(chemo)therapy for locally advanced squamous cell carcinoma of the head and neck at the Department of Radiation Oncology, Medical Center, University Freiburg, Germany, were included. The main focus was a predefined recording of mucositis. For this purpose, a clinical examination of the patients was performed twice a week by a specially trained examiner. This involved systematic