ESTRO 2024 - Abstract Book

S1417

Clinical - Head & neck

ESTRO 2024

for the best induction- and concomitant chemotherapy combinations with IMRT is still ongoing waiting for validation with longer follow-up and stronger evidence.

Keywords: NPC, induction TPF vs GP, IMRT.

References:

1. CHEN, Yu-Pei, ISMAILA, Nofisat, CHUA, Melvin LK, et al. Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline. Journal of Clinical Oncology, 2021, vol. 39, no 7, p. 840-859.

2. BOSSI, P., CHAN, A. T., LICITRA, L., et al. Nasopharyngeal carcinoma: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 2021, vol. 32, no 4, p. 452-465.

3. SUN, Ying, LI, Wen-Fei, CHEN, Nian-Yong, et al. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial. The lancet oncology, 2016, vol. 17, no 11, p. 1509-1520. 4. FRIKHA, M., AUPERIN, A., TAO, Y., et al. A randomized trial of induction docetaxel – cisplatin – 5FU followed by concomitant cisplatin-RT versus concomitant cisplatin-RT in nasopharyngeal carcinoma (GORTEC 2006-02). Annals of Oncology, 2018, vol. 29, no 3, p. 731-736.

5. ZHANG, Yuan, CHEN, Lei, HU, Guo-Qing, et al. Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma. New England Journal of Medicine, 2019, vol. 381, no 12, p. 1124-1135.

2660

Digital Poster

Three dimensional tumour volume predicts early response in recurrent oropharyngeal cancer

Parveen Ahlawat, Sarthak Tandon, Sandeep Purohit, Akash R Bellige, Sauharda Lohani, Gerim Prasai, Shaifali Mahajan, Aslam Najeem, Apoorva Nayak, Munish Gairola

Rajiv Gandhi Cancer Institute and Research Centre, Radiation Oncology, New Delhi, India

Purpose/Objective:

Recurrent oropharyngeal cancer invade and spread in different direction into the surrounding soft tissues. Largest extent of such tumour in one dimension may not necessarily represent true tumour burden, hence T stage based on maximum tumour dimension may not be the correct method to stage these tumour. Many previous studies has shown that there exist direct correlation between 3-dimensional tumour volume and prognosis in newly diagnosed head and neck cancer treated with radical radiotherapy, however there is no studies done in recurrent setting for oropharyngeal cancer who underwent reirradiation (Re-RT). The aim of this study was to determine the impact of