ESTRO 2024 - Abstract Book

S4597

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Conclusion:

LEOPARD was shown to be a very promising method of strongly increasing LET in selective subvolumes of a target, while keeping dosimetric quality. The arc boost was superior to conventional in-field boosts. Multi-ion LEOPARD could maintain very high LET to combat hypoxia, while further reducing the LET in the high dose falloff around the tumor for a potentially lower toxicity. Due to the low and homogeneous additional dose to the healthy tissue, LEOPARD could also serve as a tool to adapt to variable hypoxic subvolumes.

Keywords: particle arc therapy, LET boost, hypoxic VOI

References:

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