ESTRO 2024 - Abstract Book

S4604

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Figure 2 Coronal view of single beam contributions (B1 and B2) in a IMPT multi-field dose-based (a-b) and LET d -based (c-d) optimized plans. Plotted contours are the brainstem (yellow line), the CTV (cyan line) and GTV (red line).

Conclusion:

LET d -based objectives improved the distribution of single beam contributions, in a multi-field IMPT plan (Figure 2), driving the optimizer towards solutions otherwise hardly achievable via standard robust optimization. New optimization strategies, adopting physical quantities beyond absorbed dose, may lead to superior dose distributions in challenging patient cohorts, while accounting for RBE variability without the aid of intrinsically uncertain rabiobiological parameters.

Keywords: protontherapy LET-optimization brainstem-sparing

References:

1 Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, et al. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys. 2019; 46(3):e53-78.