ESTRO 2024 - Abstract Book

S713

Clinical - Breast

ESTRO 2024

We observed that PON1 activity, VLDL concentrations, IL-10, and TGF- β were the most important parameters for discriminating between breast cancer patients and controls.

It is necessary to advance and deepen the knowledge of the mechanisms involved in cancer to have biomarkers and thus be able to personalize oncological treatments. In this study we are currently analysing the changes produced by the different oncological treatments that patients receive (surgery, chemotherapy, radiotherapy, therapeutic targets) that we hope to be able to present at the congress.

Keywords: biomarkers, radiotherapy, chemotherapy, new targeted therapies, surgery, inflammation, oxidative stress, oncological treatment response.

*This research was funded by VARIAN, a research grants 2020-21. The funders had no role in study design, data collection and analysis, publication decisions, or manuscript preparation.

Keywords: cytokines

3009

Digital Poster

External beam partial breast re-irradiation in the conservative retreatment of BC local recurrence

Chiara Lorubbio 1,2 , Simona Arculeo 1 , Samuele Frassoni 3 , Maria Alessia Zerella 1 , Marianna Gerardi 1 , Cristiana Fodor 1 , Paolo Veronesi 2,4 , Viviana Enrica Galimberti 4 , Ekaterina Milovanova 1 , Damaris Patricia Rojas 1 , Samantha Dicuonzo 1 , Anna Morra 1 , Mattia Zaffaroni 1 , Federica Cattani 5 , Vincenzo Bagnardi 3 , Roberto Orecchia 6 , Barbara Alicja Jereczek Fossa 1,2 , Maria Cristina Leonardi 1 1 European Institute of Oncology, Division of Radiation Oncology, Milan, Italy. 2 University of Milan, Department of Oncology and Hemato-oncology, Milan, Italy. 3 Bicocca University, Department of Statistics and Quantitative Methods, Milan, Italy. 4 European Institute of Oncology, Division of Breast Surgery, Milan, Italy. 5 European Institute of Oncology, Unit of Medical Physics, Milan, Italy. 6 European Institute of Oncology, Scientific Directorate, Milan, Italy

Purpose/Objective:

To evaluate the outcome of partial breast re-irradiation (re-PBI) with intensity modulated RT (IMRT), using a hypofractionated scheme for breast cancer (BC) local recurrence (LR) operated on with repeat breast conserving surgery (BCS)

Material/Methods:

IMRT-based re-PBI was performed using either helical or step-and-shoot modality to deliver 37.05 Gy in 13 fractions in 2.5 weeks. Cumulative incidence (CumI) of 2ndLR , side effects and survival outcomes (overall, OS, specific, BCSS and disease-free, DFS) were evaluated.