ESTRO 2024 - Abstract Book

S1249

Clinical - Head & neck

ESTRO 2024

A total of 274 patients with ACE-27 scores of 0-1 were included. Median age was 63 [56, 68] years. 116 (42.3%) patients had an ACE-27 score of 1 (i.e., mild comorbidity). Of these patients, 53 (45.7%) had grade 1 (well-controlled) hypertension, 25 (21.6%) respiratory disease, and 21 (18.1%) diabetes mellitus on oral medications. Patients with an ACE-27 score of 1 reported more problems with mobility (29.3% vs 10.8%, p<0.001) vs those with an ACE-27 score of 0. Although the percentages of patients with an ACE-27 score of 1 reporting HR-QoL problems were higher in all domains, there were no significant differences for self-care (13.8% vs 6.3%, p=0.152), usual activities (32.8% vs 24.7%, p=0.182), pain/discomfort (69.0% vs 58.9%, p=0.175), and anxiety/depression (60.3% vs 50.6%, p=0.175) between groups.

On ordinal regression, an ACE-27 score of 1 was associated with increased severity in mobility, self-care, pain/discomfort, and anxiety/depression vs an ACE-27 score of 0 (Table 1).

Figure 1 Percentage of patients with an ACE score of 0 or 1 reporting problems within each EQ-5D-5L domain

Table 1 Results of the ordinal regression evaluating the association between ACE scores of 0 vs 1 (reference is 0) and the severity of each EQ-5D-5L domain.

Conclusion:

Patients with mild comorbidity experience more HR-QoL-related problems, particularly in mobility compared to patients with no comorbidity. When accounting for severity, problems with mobility, self-care, pain/discomfort, and anxiety/depression are significantly worse in patients with mild comorbidity as reported via ePROMs. This highlights the need for adequate supportive care in patients with mild comorbidity, which may have been previously overlooked.