ESTRO 2024 - Abstract Book

S4601

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Figure 2: Transmission pencil beam contribution to the IMPT&TPB plan for the oropharynx case with the CTV volume closest to the population mean from the axial plane. TPB were chosen by the optimiser to shoot between the parotids and the CTV.

On average, plans constituted of 1415 BPs and 1012 TPBs using 220 energy layers for IMPT&TPB and 1737 BPs using 230 energy layers for IMPT.

On average, IMPT planning required 118 minutes for optimisation and 94 minutes for dose computation, while IMPT&TPB planning involved 199 minutes of optimisation and 208 minutes of dose computation, using a fixed CPU/GPU on our computer cluster.

Conclusion:

The developed optimiser for fully-automated combined optimisation of IMPT Bragg peaks and transmission pencil beams was able to significantly reduce OAR doses in head-and-neck cancer by using transmission pencil beams to enhance lateral target dose fall-off.

Keywords: Transmission proton beams, IMPT, automated

References:

1. Kong, W., et al. "OC-0287 Fast and fully-automated robust multi-criterial IMPT planning via sparsity induced spot selection." Radiotherapy and Oncology 182 (2023): S222-S223.

2. Breedveld, Sebastiaan, et al. "iCycle: Integrated, multicriterial beam angle, and profile optimization for generation of coplanar and noncoplanar IMRT plans." Medical physics 39.2 (2012): 951-963.