ESTRO 2024 - Abstract Book

S4610

Physics - Optimisation, algorithms and applications for ion beam treatment planning

ESTR0 2024

Conclusion:

In a simple phantom geometry LET and Q eff showed the same spatial patterns and were also found to be closely related at a voxel level. In the pediatric brain geometry, similar RBE weighted doses were therefore observed among RBE models whether they were based on LET d or Q eff,d . The absolute RBE values evaluated by RBE models based on LET d and Q eff,d showed minor variations depending on whether LET d and Q eff,d were considered as variables, but the choice of the specific model had more impact. However, the qualitative distribution of RBE remained consistent with the result that the highest RBE-weighted doses were located at the distal end of the fields, independent of whether RBE was described using LET or Q eff .

Keywords: proton therapy, treatment planning, modellering

887

Digital Poster

Time is NTCP: should we prioritize patient throughput or online adaptation for proton therapy?

Elena Borderias 1 , Ana Barragan 1 , Edmond Sterpin 2,1,3

1 UCLouvain, MIRO, Brussels, Belgium. 2 KU Leuven, Department of Oncology, Leuven, Belgium. 3 Particle Therapy Center Leuven, PARTICLE, Leuven, Belgium

Purpose/Objective:

Compared to conventional radiotherapy (XT), proton therapy (PT) may improve normal tissue complication probabilities (NTCP). However, PT typically requires higher adaptation rates due to an increased sensitivity to