ESTRO 2024 - Abstract Book

S5419

Radiobiology - Tumour biology

ESTRO 2024

This study identifies that the expression of sex-linked genes is altered in tumour compared to normal lung tissue and that these genes can affect the expression levels DDR and senescence genes in tumours. In patient cohorts segregated according to recorded sex, statistically significant associations between expression levels in tours to overall survival could be detected. Further analysis of the biological and clinical relevance of these links to the radiation response and patient outcome is warranted.

Keywords: sex, lung cancer, DNA damage, senescence

References:

1 De Courcy, L., Bezak, E. & Marcu, L. G. Gender-dependent radiotherapy: The next step in personalised medicine? Crit Rev Oncol Hematol 147, 102881, doi:10.1016/j.critrevonc.2020.102881 (2020).

2 He, Y. et al. Cancer-specific survival after diagnosis in men versus women: A pan-cancer analysis. MedComm (2020) 3, e145, doi:10.1002/mco2.145 (2022).

3 Shohat, S., Vol, E. & Shifman, S. Gene essentiality in cancer cell lines is modified by the sex chromosomes. Genome Res 32, 1993-2002, doi:10.1101/gr.276488.121 (2022).

4 Achilla, C., Papavramidis, T., Angelis, L. & Chatzikyriakidou, A. The Implication of X-Linked Genetic Polymorphisms in Susceptibility and Sexual Dimorphism of Cancer. Anticancer Res 42, 2261-2276, doi:10.21873/anticanres.15706 (2022).

2611

Digital Poster

Alpha/Beta Ratios in Medulloblastoma: A Step Towards Personalized Radiotherapeutic Strategies

Danny Jazmati, Dennis Sohn, Jan Haussmann, Edwin Boelke, Balint Tamaskovics, Ronja-Linda Preugschas, Niklas Niggemeier, Marc Remke, Nan Qin, Wilfried Budach, Christiane Matuschek

Heinrich Heine University, Radiation Oncology, Dusseldorf, Germany

Purpose/Objective:

Medulloblastoma is a prevalent pediatric brain tumor, with current treatment protocols emphasizing the pivotal role of craniospinal irradiation (CSI). This study aims to elucidate the optimal radiotherapeutic fractionation by investigating the alpha/beta ratios, intending to enhance treatment personalization and improve survival outcomes.

Material/Methods: