ESTRO 2024 - Abstract Book

S5421

Radiobiology - Tumour biology

ESTRO 2024

Conclusion:

This study offers valuable insights into the radiotherapeutic fractionation strategies in pediatric medulloblastoma treatment, highlighting the complexities involved in optimizing therapeutic outcomes. It propels the notion of a more molecularly tailored approach, bolstered by comprehensive genetic subgroup analysis, aiming for the development and implementation of personalized treatment protocols in managing medulloblastoma

Keywords: Alpha/Beta Ratios , medulloblastoma, radiation

2646

Proffered Paper

Enhancing Radiosensitization by Targeting SETD2 in Rectal Cancer

Adam R Wolfe, Lokesh Akana, Henrique Rodrigues, Oscar Zuniga, Saaimatul Huq

University of Arakansas for Medical Sciences, Radiation Oncology, Little Rock, USA

Purpose/Objective:

Tri-methyl-histone H3 (Lys36) is a histone H3 modification that plays a vital role in gene regulation and the organization of chromatin. 1 It also influences the response of cells to ionizing radiation and the repair of DNA damage. 2 Altered levels of this modification have been associated with reduced sensitivity to radiation. We propose the hypothesis that by targeting SETD2, the enzyme responsible for adding the tri-methyl group to Lys36 of histone H3 3 , we may enhance the radiosensitivity of rectal cancer cells.