ESTRO 2024 - Abstract Book

S5431

Radiobiology - Tumour biology

ESTRO 2024

[1] McGuigan, Andrew; Kelly, Paul; Turkington, Richard C.; Jones, Claire; Coleman, Helen G.; McCain, R. Stephen (2018): Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. In: WJG 24 (43), S. 4846– 4861. DOI: 10.3748/wjg.v24.i43.4846. [2] Combs, Stephanie E.; Habermehl, Daniel; Kessel, Kerstin A.; Bergmann, Frank; Werner, Jens; Naumann, Patrick et al. (2014): Prognostic impact of CA 19-9 on outcome after neoadjuvant chemoradiation in patients with locally advanced pancreatic cancer. In: Annals of surgical oncology 21 (8), S. 2801–2807. DOI: 10.1245/s10434-014-3607-8. [3] Wu, Xiaoqing; Tang, Wenhua; Marquez, Rebecca T.; Li, Ke; Highfill, Chad A.; He, Fengtian et al. (2016): Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling. In: Oncotarget 7 (10), S. 11708–11723. DOI: 10.18632/oncotarget.7336. [4] Wiechmann, Svenja; Saupp, Elena; Schilling, Daniela; Heinzlmeir, Stephanie; Schneider, Günter; Schmid, Roland M. et al. (2020): Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells. In: Molecular & cellular proteomics : MCP 19 (10), S. 1649–1663. DOI: 10.1074/mcp.RA120.002046.

2834

Proffered Paper

ALDH1A1 and PLK3 as promising therapeutic targets in prostate cancer metastasis and radioresistance

Ielizaveta Gorodetska 1,2 , Anne Offermann 3,4 , Jakob Püschel 1,2 , Vasyl Lukiyanchuk 1,2 , Diana Gaete 5 , Anastasia Kurzyukova 6 , Christina Sæten Fjeldbo 7 , Annett Linge 1,8,9 , Steffen Löck 10 , Shivaprasad Patil 10 , Vera Freytag 11 , Tobias Lange 11 , Franziska Knopf 6 , Ben Wielockx 5 , Heidi Lyng 7 , Mechthild Krause 1,9,12 , Sven Perner 3,4 , Anna Dubrovska 1,2,13 1 OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Radiobiology, Dresden, Germany. 2 Helmholtz-Zentrum Dresden – Rossendorf, Institute of radiooncology, Dresden, Germany. 3 Institute of Pathology, University Hospital Schleswig-Holstein, Pathology, Luebeck, Germany. 4 Pathology, Research Center Borstel, Leibniz Lung Center, Pathology, Borstel, Germany. 5 Institute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Biology, Dresden, Germany. 6 Technische Universität Dresden, CRTD - Center for Regenerative Therapies TU Dresden, Center for Healthy Aging, Biology, Dresden, Germany. 7 Institute for Cancer Research, Oslo University Hospital, Department of Radiation Biology, Oslo, Norway. 8 Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Department of Radiotherapy and Radiation Oncology, Dresden, Germany. 9 German Cancer consortium (DKZTK) Dresden and German Cancer Research Center (DKFZ), Translational Radiation Oncology, Heidelberg, Germany. 10 OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden Rossendorf, Medical Physics, Dresden, Germany. 11 Institute of Anatomy and Experimental Morphology, Center for Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Oncology, Hamburg, Germany. 12 National Center for Tumor Diseases (NCT), Radiation oncology, Dresden, Germany. 13 German Cancer consortium (DKZTK) Dresden and German Cancer Research Center (DKFZ), Oncology, Heidelberg, Germany