ESTRO 2024 - Abstract Book

S5287 ESTRO 2024 Pectin and psyllium plus pectin were shown to protect the lower gut against ionising radiation toxicity by preventing shrinkage in caecal surface area and increasing the number of regenerating intestinal crypts post irradiation. This could be a useful treatment for acute intestinal radiation toxicity in humans. Radiobiology - Normal tissue radiobiology

Keywords: Dietary fibre, pectin, normal tissue toxicity

References:

1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A: Erratum: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2020, 70(4):313.

2. Pilleron S, Alqurini N, Ferlay J, Haase KR, Hannan M, Janssen-Heijnen M, Kantilal K, Katanoda K, Kenis C, Lu-Yao G: International trends in cancer incidence in middle-aged and older adults in 44 countries. Journal of Geriatric Oncology 2022, 13(3):346-355.

3. Turrentine FE, Wang H, Simpson VB, Jones RS: Surgical risk factors, morbidity, and mortality in elderly patients. J Am Coll Surg 2006, 203(6):865-877.

4. Groselj B, Ruan J, Scott H, Gorrill J, Nicholson J, Kelly J, Anbalagan S, Thompson J, Stratford MR, Jevons SJ: Radiosensitization in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity. Molecular cancer therapeutics 2018, 17(2):381-392. 5. Ruan J, Lee C, Wouters S, Tullis ID, Verslegers M, Mysara M, Then CK, Smart SC, Hill MA, Muschel RJ: Irradiation at ultra-high (FLASH) dose rates reduces acute normal tissue toxicity in the mouse gastrointestinal system. International Journal of Radiation Oncology* Biology* Physics 2021, 111(5):1250-1261.

6. Then CK, Paillas S, Wang X, Hampson A, Kiltie AE: Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation. BMC Biology 2020, 18:1-16.

7. MetaHIT Consortium: Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR. Tap J., Bruls T., et al.Enterotypes of the human gut microbiome.Nature 2011, 473:174-180.

8. Eaton SE, Kaczmarek J, Mahmood D, McDiarmid AM, Norarfan AN, Scott EG, Then CK, Tsui HY, Kiltie AE: Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients. Br J Cancer 2022, 127(12):2087-2098.

9. Ewaschuk JB, Dieleman LA: Probiotics and prebiotics in chronic inflammatory bowel diseases. World journal of gastroenterology: WJG 2006, 12(37):5941.

10. Blanco-Pérez F, Steigerwald H, Schülke S, Vieths S, Toda M, Scheurer S: The dietary fibre pectin: Health benefits and potential for the treatment of allergies by modulation of gut microbiota. Current Allergy and Asthma Reports 2021, 21:1-19. 11. Murphy J, Stacey D, Crook J, Thompson B, Panetta D: Testing control of radiation-induced diarrhoea with a psyllium bulking agent: a pilot study. Canadian Oncology Nursing Journal/Revue canadienne de soins infirmiers en oncologie 2000, 10(3):96-100.

2407

Digital Poster