ESTRO 2024 - Abstract Book

S5304

Radiobiology - Normal tissue radiobiology

ESTRO 2024

Figure 1: Relationship between dose and percentage of irradiated mice with acute skin toxicity. Dose-response curves for two different levels of skin damage compare the broad beam and pMBRT irradiation modalities, demonstrating increased normal tissue sparing using pMBRT. pMBRT doses are nominal doses which yield the same PTV dose as the conventional plan, to ensure comparability.

Conclusion:

Our study underscores a discernible biological gain for pMBRT with a homogeneous target dose, offering strong premises for its broader clinical implementation. The GF terminology can be used to characterize pMBRT efficacy when the target volume is homogenous, without relying on dose averaging of grid patterns.

Keywords: pMBRT, SFRT,

References:

1. Prezado, Y. Divide and conquer: spatially fractionated radiation therapy. Expert Reviews in Molecular Medicine 24, e3 (2022).

2. Prezado, Y. et al. Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas. Scientific reports 8, 16479–10 (2018).

3. Prezado, Y. et al. Tumor Control in RG2 Glioma-Bearing Rats: A Comparison Between Proton Minibeam Therapy and Standard Proton Therapy. International Journal of Radiation Oncology*Biology*Physics 104, 266–271 (2019).