ESTRO 2024 - Abstract Book

S526

Clinical - Breast

ESTRO 2024

1. Holm Milo ML, Slot Møller D, Bisballe Nyeng T, Hoffmann L, Dahl Nissen H, Jensen I, et al. Radiation dose to heart and cardiac substructures and risk of coronary artery disease in early breast cancer patients: A DBCG study based on modern radiation therapy techniques. Radiother Oncol [Internet]. 2023;180(109453):109453. Available: http://dx.doi.org/10.1016/j.radonc.2022.109453 2. Petit C, Escande A, Sarrade T, Vaugier L, Kirova Y, Tallet A. Radiation therapy in the thoracic region: Radio-induced cardiovascular disease, cardiac delineation and sparing, cardiac dose constraints, and cardiac implantable electronic devices. Cancer Radiother [Internet]. 2023;27(6 – 7):588 – 98. Available: http://dx.doi.org/10.1016/j.canrad.2023.06.027 3. Kirova Y, Tallet A, Aznar MC, Loap P, Bouali A, Bourgier C. Radio-induced cardiotoxicity: From physiopathology and risk factors to adaptation of radiotherapy treatment planning and recommended cardiac follow-up. Cancer Radiother [Internet]. 2020;24(6 – 7):576 – 85. Available: http://dx.doi.org/10.1016/j.canrad.2020.07.001 4.Naimi Z, Moujahed R, Neji H, Yahyaoui J, Hamdoun A, Bohli M, et al. Cardiac substructures exposure in left-sided breast cancer radiotherapy: Is the mean heart dose a reliable predictor of cardiac toxicity? Cancer Radiother [Internet]. 2021;25(3):229 – 36. Available: http://dx.doi.org/10.1016/j.canrad.2020.09.003 5. Eber J, Schmitt M, Dehaynin N, Le Fèvre C, Antoni D, Noël G. Evaluation of cardiac substructures exposure of DIBH-3DCRT, FB-HT, and FB-3DCRT in hypofractionated radiotherapy for left-sided breast cancer after breast conserving surgery: An in silico planning study. Cancers (Basel) [Internet]. 2023;15(13):3406. Available: http://dx.doi.org/10.3390/cancers15133406 6. Shen J, Gu P, Wang Y, Wang Z. Advances in automatic delineation of target volume and cardiac substructure in breast cancer radiotherapy (Review). Oncol Lett [Internet]. 2023;25(3). Available: http://dx.doi.org/10.3892/ol.2023.1369

962

Digital Poster

Preoperative MR-guided single-dose partial breast irradiation: the ABLATIVE-2 trial (NCT05350722)

Yasmin Civil 1 , Nienke Weitkamp 1 , Myrian Rinzema 1 , Katya Duvivier 2 , Lorraine Donkers 1 , Omar Bohoudi 1 , Anna Bruynzeel 1 , Ben Slotman 1 , Zdenko van Kesteren 1 , Miguel Palacios 1 , Desirée van den Bongard 1 1 Amsterdam UMC, Radiation Oncology, Amsterdam, Netherlands. 2 Amsterdam UMC, Radiology, Amsterdam, Netherlands

Purpose/Objective:

Preoperative radiotherapy instead of standard postoperative partial breast irradiation (PBI) allows more precise target delineation with smaller treatment volumes, and could lead to reduced radiation-induced toxicity and improved cosmetic outcomes. In addition, preoperative PBI may induce tumor downstaging, enabling response monitoring, and may result in a reduction of excision volumes during breast-conserving surgery (1-2). MR imaging is used to improve motion management during the radiation delivery process and enhance treatment precision compared to conventional CT-guided PBI. In addition, it eliminates the need for inserting an additional fiducial to