ESTRO 2024 - Abstract Book

S5388

Radiobiology - Tumour biology

ESTRO 2024

Conclusion:

Phase II ROCK trials enrolled 22 patients; this little number limits the statistical power of results obtained in translational studies. Transcriptome analysis indicates an enrichment in genes related to p53 signaling and DNA damage response. In R-R patients, expression of CCDC97 is significantly increased. CCDC97 is an orphan gene that has been identified among nuclear interaction partners of an interactome enriched in DNA damage repair-related factors (1). IHC analysis shows that the positive effect of prRS in terms of tumor downstaging may reflect the different immune microenvironment composition of early breast cancer patients. Our data underline the importance of genetic background and TIME in response to radiosurgery. The overexpression of CCDC97 in R-R patients makes worthy further investigations on the role of this orphan gene in response to radiation, particularly to extreme hypofractionation.

Keywords: breast cancer, transcriptomics, immune-infiltrate

References:

1.Guard SE, Poss ZC, Ebmeier CC, Pagratis M, Simpson H, Taatjes DJ, Old WM. The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair. Sci Rep. 2019 Apr 25;9(1):6539.