ESTRO 2024 - Abstract Book

S5437

Radiobiology - Tumour biology

ESTRO 2024

References:

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Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. cell. 2011;144(5):646-674.

Sperduto PW, Yang TJ, Beal K, et al. Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol. Jun 1 2017;3(6):827-831. doi:10.1001/jamaoncol.2016.3834

Roś-Mazurczyk M, Wojakowska A, Marczak Ł, et al. Ionizing radiation induces changes in profile of metabolites in serum of cancer patients. Acta Biochimica Polonica. 2017;64(1):189-193.

Fahrmann JF, Grapov DD, Wanichthanarak K, et al. Integrated Metabolomics and Proteomics Highlight Altered Nicotinamide- and Polyamine Pathways in Lung Adenocarcinoma. Carcinogenesis. Mar 2017;38(3):271-280. doi:10.1093/carcin/bgw205

3077

Digital Poster

Microbeam Radiation controls in vivo tumors more effectively than conventional radiation treatment

Mabroor Ahmed 1,2 , Manuel Bernabai 1,3 , Narayani Subramanian 1,3 , Aleksandra Čolić 1,3 , Marina S Franco 1,3 , Jessica Stolz 1,3 , Susanne Raulefs 1,3 , Stephanie E Combs 1,3 , Thomas E Schmid 1,3 , Stefan Bartzsch 1,3 1 Helmholtz Zentrum München, Institute of Radiation Medicine, Neuherberg, Germany. 2 Technical University of Munich, School of Natural Sciences, Department of Physics, Garching, Germany. 3 Technical University of Munich, Klinikum rechts der Isar, School of Medicine and Health, Department of Radiation Oncology, München, Germany

Purpose/Objective:

Microbeam Radiotherapy (MRT) is a novel approach of treating cancer with ionizing radiation (IR), where dose is applied spatially fractionated, leading to high-dose peak and low-dose valley-regions. This principle has proven to not only lead to increased normal tissue tolerance [1] but has also shown the ability to combat tumors more effectively [2]. The latter aspect is the focus of our research, where we are interested in the tumor control probability of MRT compared to conventional uniform doses.

Material/Methods:

A549 cells (a human non-small cell lung cancer cell line) were injected subcutaneously into the right flank of immunocompromised CD-1 Foxn1nu mice. Once the tumors had reached a volume of >= 60mm³ they were irradiated