ESTRO 2024 - Abstract Book

S542

Clinical - Breast

ESTRO 2024

equivocal cases. However, it was associated with both false positives and false negatives in our series and this should be borne in mind when counselling patients regarding subsequent surgical intervention.

Keywords: Brain metastases, MRI CCA, TRAMs

References:

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[2] Lee Y-TN (Margaret). Breast carcinoma: Pattern of metastasis at autopsy. J Surg Oncol 1983;23:175 – 80. https://doi.org/10.1002/jso.2930230311.

[3] Zimmer AS, D Van Swearingen AE, Anders CK, Carey Anders CK, Duke Health Scholar T. HER2-positive breast cancer brain metastasis: A new and exciting landscape 2020. https://doi.org/10.1002/cnr2.1274.

[4] Corti C, Antonarelli G, Criscitiello C, Lin NU, Carey LA, Cortés J, et al. Targeting brain metastases in breast cancer. Cancer Treat Rev 2022;103:102324. https://doi.org/10.1016/j.ctrv.2021.102324.

[5] Le Rhun E, Guckenberger M, Smits M, Dummer R, Bachelot T, Sahm F, et al. EANO – ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours. Annals of Oncology 2021;32:1332 – 47. https://doi.org/10.1016/j.annonc.2021.07.016. [6] Lehrer EJ, Kowalchuk RO, Ruiz-Garcia H, Merrell KW, Brown PD, Palmer JD, et al. Preoperative stereotactic radiosurgery in the management of brain metastases and gliomas. Front Surg 2022;9. https://doi.org/10.3389/fsurg.2022.972727.

[7] Zach L, Guez D, Last D, Daniels D, Grober Y, Nissim O, et al. Delayed contrast extravasation MRI: a new paradigm in neuro-oncology. Neuro Oncol 2015;17:457 – 65. https://doi.org/10.1093/neuonc/nou230.

[8] Bodensohn R, Forbrig R, Quach S, Reis J, Boulesteix A-L, Mansmann U, et al. MRI-based contrast clearance analysis shows high differentiation accuracy between radiation-induced reactions and progressive disease after cranial radiotherapy. ESMO Open 2022;7:100424. https://doi.org/10.1016/j.esmoop.2022.100424.

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Cosmetic outcome after APBI using intraoperative or external beam radiotherapy (NTR2931)

Jetske L.B. Gunster 1,2 , Daphne H.M. Jacobs 3 , Mirjam E. Mast 3 , Ursula Fisscher 3 , Anna L. Petoukhova 4 , Gabrielle Speijer 5 , Marieke Straver 6 , Jos Merkus 7 , Corrie A.M. Marijnen 1,2 , Antoinette Verbeek-de Kanter 3 , Astrid N. Scholten 1