ESTRO 2024 - Abstract Book

S5680

RTT - Patient experience and quality of life

ESTRO 2024

Simple analgesia (grade 1), such as paracetamol, was recommended to the majority of HNC patients in week 1. Patients in this study, who are took milder opioids such as co-codamol, will show as a score of 3 or 4, as it is not graded by dose and strength, which could be a future a recommendation (3). The results in this study are comparable to current research, where patients did not experience grade 4 oral cavity toxicity (4). A contemporary study (5) produced similar skin toxicity data to this study. However, the RTOG grading system is limiting as it is difficult to use for patients with darker skin tones. Patients that started treatment with constipation can skew the data as the bowel impact is not caused by starting analgesia whilst on treatment (6). There were some inter-professional inconsistencies with electronic proforma completion for earlier HNC patients during the phase when the proforma was being established. This resulted in some omissions of data for earlier patients. Fatigue outcomes are now a standard proforma addition. Males had a higher acute side-effect incidence, which could be explored further in forthcoming research, in particular the psychological impact of treatment, which could form its own research study. Acute side-effect trends may not be discernible from this study, however future data collection could further separate patients into diagnostic cohorts.

Keywords: "proton", "head and neck", "acute"

References:

1) Holliday, E.B, and Fran, S. J. Proton Radiation Therapy for Head and Neck Cancer: A Review of the Clinical Experience to Date. International Journal of Radiation Oncology Biology Physics. Volume 89 (2), 2014, 292-302.

2) Abdelmeguid, A.S., Bell, D., Roberts, D., Ferrarotto, R., Phan, J., Su, S.Y., Kupferman, M., Raza, S., DeMonte, F. and Hanna, E. (2022), Long-Term Outcomes of Olfactory Neuroblastoma: MD Anderson Cancer Center Experience and Review of the Literature. The Laryngoscope, 132: 290-297. https://doi.org/10.1002/lary.29732 3) Fang, K-C., Lee, C-H., Chuang, H-C., Huang, T-L., Chien, C-Y., Tsai, W-L. and Fang, F-M. (2023). Acute radiation dermatitis among patients with nasopharyngeal carcinoma treated with proton beam therapy: Prognostic factors and treatment outcomes. International Wound Journal. 20 (2), 499-609. 4) McDonald, M.W, Liu, Y., Moore, M.G. and Johnstone, P.A.S. (2016). Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy. Radiation Oncology. 11:32 DOI 10.1186/s13014-016-0600-3 5) Fang, K-C., Lee, C-H., Chuang, H-C., Huang, T-L., Chien, C-Y., Tsai, W-L. and Fang, F-M. (2023). Acute radiation dermatitis among patients with nasopharyngeal carcinoma treated with proton beam therapy: Prognostic factors and treatment outcomes. International Wound Journal. 20 (2), 499-609. 6) Löser, A., Avanesov, M., Thieme, A., Gargioni, E., Baehr, A., Hintelmann, K., Tribius, S., Krüll, A. and Petersen, C. (2022). Nutritional Status Impacts Quality of Life in Head and Neck Cancer Patients Undergoing (Chemo)Radiotherapy: Re sults from the Prospective HEADNUT Trial. Nutrition and Cancer. 74 (8), 2887-2895.

1624

Proffered Paper

Evaluating the impact of radiotherapy late effects against the NHS Cancer Quality of Life survey