ESTRO 2024 - Abstract Book

S624

Clinical - Breast

ESTRO 2024

The majority of loco-regional failures in high-risk breast cancer patients treated with adjuvant radiotherapy according to the ESTRO guideline and diagnosed with loco-regional failure were detected inside the high-dose volume of radiation. This pattern of failure is in strong support of the feasibility of the ESTRO consensus guideline indicating that there appears no need to expand the size of the nodal targets. As pre-specified, the loco-regional pattern of failure for the entire cohort in the DBCG Skagen trial 1 will be performed.

Keywords: ESTRO consensus, breast cancer, pattern of failure

References:

1. Offersen, B.V., L.J. Boersma, C. Kirkove, S. Hol, M.C. Aznar, A. Biete Sola, et al. ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother Oncol, 2015. 114(1): p. 3-10 DOI: 10.1016/j.radonc.2014.11.030. 2. Danish Breast Cancer Cooperative Group Radiotherapy, C. Postoperativ strålebehandling af brystkræft. 2023 10.03.2023; 3.0:[Available from: https://www.dmcg.dk/siteassets/kliniske-retningslinjer---skabeloner-og vejledninger/kliniske-retningslinjer-opdelt-pa dmcg/dbcg/dbcg_postop_stralebh_brystkraft_v.3.0_admgodk_10032023.pdf.

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Digital Poster

Risk of second cancers after radiotherapy for breast cancer: A systematic review and meta-analysis

Fateme Salemi 1 , Farzam Salari 1 , Sara Jambarsang 2 , Mohammad Reza Mortazavizadeh 3 , Negar Nejati 4

1 Shahid Sadoughi University of Medical sciences, Oncology, Yazd, Iran, Islamic Republic of. 2 Shahid Sadoughi University of Medical sciences, Biostatistics, Yazd, Iran, Islamic Republic of. 3 Islamic Azad University School of Medicine, Oncology, Yazd, Iran, Islamic Republic of. 4 Tehran University of medical Sciences, Oncology, Tehran, Iran, Islamic Republic of

Purpose/Objective:

Radiation therapy for breast cancer reduces the risk of regional recurrence and improves patients’ survival. However, large-scale cancer registry-based studies and smaller single institutional studies have shown the association of breast irradiation with secondary malignancies specifically in organs adjacent to the radiation fields. This systematic review and meta-analysis aimed to assess the risk of radiation-induced secondary malignancies and discuss both direct and indirect effects of breast radiotherapy in long-term follow-ups.

Material/Methods: