ESTRO 2024 - Abstract Book

S58 ESTRO 2024 effective clinical research. By identifying specific areas within the RTT scope of practice which are directly relevant to clinical research, the RTT can be an integral professional to drive the facilitation and implementation of clinical trials. RTTs are innovative cancer experts and RTT-led research provide a myriad of benefits to the patient, service, and individual professional development; however, the correct infrastructure is vital, and fundamental challenges need to be addressed. Invited Speaker

Conclusions

Leadership and advocacy are needed to elevate the benefits of RTTs in clinical research. The impact RTTs can make is unquestionable but the return of investment in how this can contribute to the patient care in every day practice needs to be realised and quantified. Interdisciplinary collaboration, promoting the role of the RTT and seeking role models and mentorship could provide greater access for clinical research inclusion.

3374

Learning from dose effects in routinely collected data

Alan McWilliam

Division of Cancer Science, University of Manchester, Manchester, United Kingdom

Abstract:

In this presentation, I will introduce the concepts of modelling dose effects in routinely collected data. The benefits and limitations of DVH based analysis, voxel-based analysis and machine learning approaches will be discussed. The case for strong engagement with clinical teams and the need for validation experiments will be presented. Often, dose effect modelling does not define a mechanism, we will discuss potential avenues to test mechanistic hypothesis for dose effect modelling results. A exemplar of how results from dose effect modelling can be translated into the clinic will be presented to highlight the potential of these studies. Finally, to ensure the dose effect associations we discover in these experiments are true, we will discuss if revisiting studies from a causal perspective can provide more confidence in results.

3375

Learning MRI sequences: What do we see?

Vivian W. J. van Pelt

NKI-AVL, Radiotherapy, Amsterdam, Netherlands

Abstract:

Magnetic Resonance Imaging (MRI) has become an indispensable tool in radiation oncology for precise tumor delineation, treatment planning, motion monitoring and monitoring treatment response. Understanding MRI sequences is crucial for radiation therapists and oncologists to harness the full potential of this imaging modality. In