ESTRO 2024 - Abstract Book

S659

Clinical - Breast

ESTRO 2024

The primary endpoints of the study were respected: the demonstration of the dosimetric sparing of OARs using 3D CRT FIF and CPAP as opposed to treatment in free breathing (FB) and, moreover, the reduction of diaphragmatic excursion throughout the respiratory cycle as a result of increased, stable lung volumes by means of CPAP.

The aim of this prospective study is to recruit at least 50 patients to confirm these promising data.

Keywords: left-sided breast cancer, CPAP, cardiac toxicity

References:

[1] Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-Year Follow-up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer. N Engl J Med 2002;347:1233 – 41. https://doi.org/10.1056/NEJMoa022152. [2] Zhang TW, Snir J, Boldt RG, Rodrigues GB, Louie AV, Gaede S, et al. Is the Importance of Heart Dose Overstated in the Treatment of Non-Small Cell Lung Cancer? A Systematic Review of the Literature. International Journal of Radiation Oncology, Biology, Physics 2019;104:582 – 9. https://doi.org/10.1016/j.ijrobp.2018.12.044. [3] Advances in 4D Medical Imaging and 4D Radiation Therapy - Guang Li, Deborah Citrin, Kevin Camphausen, Boris Mueller, Chandra Burman, Borys Mychalczak, Robert W. Miller, Yulin Song, 2008 n.d. https://journals.sagepub.com/doi/10.1177/153303460800700109?url_ver=Z39.88 2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed (accessed October 2, 2023). [4] Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer | NEJM n.d. https://www.nejm.org/doi/10.1056/NEJMoa1209825?url_ver=Z39.88 2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.gov (accessed October 1, 2023). [5] Continuous Positive Airway Pressure for Motion Management in Stereotactic Body Radiation Therapy to the Lung: A Controlled Pilot Study - International Journal of Radiation Oncology, Biology, Physics n.d. https://www.redjournal.org/article/S0360-3016(15)00632-X/fulltext (accessed October 2, 2023). [6] The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. The Lancet 2008;371:1098 – 107. https://doi.org/10.1016/S0140 6736(08)60348-7.

2613

Poster Discussion

Preoperative single-fraction RT for earlystage BC: preliminary results from CRYSTAL phase I/II study

Maria Alessia Zerella 1 , Mattia Zaffaroni 1 , Giovanni Carlo Mazzola 1 , Giuseppe Ronci 1 , Samantha Dicuonzo 1 , Damaris Patricia Rojas 1 , Anna Morra 1 , Marianna Alessandra Gerardi 1 , Cristiana Fodor 1 , Elena Rondi 2 , Sabrina Vigorito 2 , Silvia Penco 3 , Manuela Sargenti 4 , Elisa Vicini 4 , Viviana Enrica Galimberti 4 , Sara Gandini 5 , Giulia Cursano 6 , Elisa De Camilli 6 ,