ESTRO 2024 - Abstract Book

S672

Clinical - Breast

ESTRO 2024

survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial. BMJ. 2020 Aug 19;370:m2836. doi: 10.1136/bmj.m2836. Fastner G, Gaisberger C, Kaiser J, Scherer P, Ciabattoni A, Petoukhova A, Sperk E, Poortmans P, Calvo FA, Sedlmayer F, Leonardi MC. ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer. Radiother Oncol. 2020 Aug;149:150-157. doi: 10.1016/j.radonc.2020.04.059. Veronesi U, Orecchia R, Luini A, Galimberti V, Zurrida S, Intra M, Veronesi P, Arnone P, Leonardi MC, Ciocca M, Lazzari R, Caldarella P, Rotmensz N, Sangalli C, Sances D, Maisonneuve P. Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons. Breast Cancer Res Treat. 2010 Nov;124(1):141-51. doi: 10.1007/s10549-010-1115-5. Leonardi MC, Maisonneuve P, Mastropasqua MG, Morra A, Lazzari R, Rotmensz N, Sangalli C, Luini A, Veronesi U, Orecchia R. How do the ASTRO consensus statement guidelines for the application of accelerated partial breast irradiation fit intraoperative radiotherapy? A retrospective analysis of patients treated at the European Institute of Oncology. Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):806-13. doi: 10.1016/j.ijrobp.2011.08.014.

2767

Digital Poster

Dosimetric analysis of Deep-Inspiration-Breath-Hold for right breast cancer radiotherapy

Fabio Busato, Marco Ciro Schifano, Davide Fiorentin, Mattia Nicoletto, Erick Maffi, Claudio Antonelli, Alessandro Testolin, Marco Fusella

Abano Terme Hospital, Radiation Therapy, Padova, Italy

Purpose/Objective:

Deep Inspiration Breath Hold (DIBH) is a well-established technique used to minimize radiation exposure to the heart and left anterior descending coronary artery (LAD) during treatment for left breast cancer [1].

When considering treatment for right breast cancer (R-BC), limited studies with small patient cohorts have demonstrated dosimetric advantages of DIBH in case of Regional Nodal Irradiation (RNI) [2] and hepatomegaly [3] for lung sparing. Thus, there is still a paucity of data regarding the application of DIBH in right breast cancer radiation therapy, leaving uncertainty about which patients stand to gain the most from this approach.

This study aims to evaluate the dosimetric benefits of DIBH in the locoregional irradiation of right breast cancer (R BC) using modulated radiotherapy, in comparison to Free Breathing (FB).

Material/Methods: