ESTRO 2024 - Abstract Book

S684

Clinical - Breast

ESTRO 2024

Conclusion:

A risk estimation model using a baseline ACE risk calculator sensitive to higher cardiovascular risk in specific populations and MHD is proposed for individualised estimation of the absolute risk of cardiac morbidity in breast cancer patients undergoing radiotherapy. This risk estimation may guide clinical decision-making regarding the requirement and nature of cardiac sparing radiotherapy for individual patients, based on factors that determine the baseline risk of ACE.

Keywords: ACE risk estimation, Mean Heart dose.

References:

1. Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, et al. Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. N Engl J Med. 2013 Mar 14;368(11):987 – 98

2. Hippisley-Cox J, Coupland C, Brindle P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ. 2017 May 23;j2099.