ESTRO 2024 - Abstract Book

S701

Clinical - Breast

ESTRO 2024

2. Coles, C. (2019) ‘ Dose escalated simultaneous integrated boost radiotherapy for women treated by breast conservation surgery for early breast cancer: 3- year adverse effects in the IMPORT HIGH trial (CRUK/06/003)’, San Antonio Breast Cancer Symposium, Volume 79, (4) 3. Vicini,F.A. (2022) ‘NRG RTOG 1005: A Phase 3 Trial of HypoFractionated Whole Breast Irradiation with Concurrent Boost vs. Conventional Whole Breast Irradiation Plus Sequential Boost Following Lupectomy for High Risk Early Stage Breast Cancer.’ International Journal of Radiation Oncology,Biology,Physics (Red Journal), Volume 114 (3) 4. Thomsen, M.S (2022) ‘Volume matters: Breast induration is associated with irradiated breast volume in the Danish Breast Cancer Group phase 3 randomised Partial Breast Irradiation Trial’. Radiotherapy and Oncology (The Green Journal), Volume 117, P231-235

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Digital Poster

Clinical outcomes and dosimetric study of ultrahypofractionated in breast cancer older patients

Alice Alves 1 , Daniela Saraiva 1 , Raquel Rocha 1 , Claudia Sá 2 , Catarina Elzen 1 , Filipa Martins 1 , João Casalta Lopes 1 , Pedro Meireles 1 , Maria Gabriela Pinto 1 1 Centro Hospitalar São João, Radiotherapy, Porto, Portugal. 2 Instituto Português de Oncologia de Lisboa, Radiotherapy, Lisboa, Portugal

Purpose/Objective:

Radiotherapy (RT) after breast-conserving surgery (BCS) is well established for treating breast cancer (BC) in women with early-stage cancers. It has demonstrated significant clinical benefits by reducing the recurrence rate and improving overall survival. Older adult patients with early stage BC constitute a population with regards to prognosis and potential comorbidities, minimizing treatment to maintain health-related quality of life (HRQoL) is extremely important. The Fast-Forward trial has demonstrated the effectiveness and safety of ultra fractionation (26 Gy in 5 fractions) as whole breast irradiation (WBI) treatment. The European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice has provided consensus recommendations for patient selection and dose and fractionation in external beam RT in early BC. Partial breast irradiation (PBI) can be used as an alternative treatment method for selected patients at an early stage, advantages of PBI include shorter treatment time, equivalent disease control, improved safety, and one of effective strategies to reduce cardiac radiation dose when compared to WBI. These approaches could be the most appropriate treatment for elderly patients, potentially preserving quality of life and increasing the tolerability of irradiation.

The main objective of this study is to present the clinical and dosimetric outcomes of ultrahypofractionation in elderly patients with breast cancer, who were treated with hypofractionated radiation therapy at our center.

Material/Methods: