ESTRO 2024 - Abstract Book

S744

Clinical - CNS

ESTRO 2024

There is a correlation between dose of radiation received by several encephalic regions of interest and degree of short-term domain-specific cognition decline, considering other risk factors and cognitive rehabilitation.

Keywords: neurocognition, radiotherapy

139

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Stereotactic radiosurgery in elderly patients with brain metastases from non-small cell lung cancer

Jeongshim Lee 1 , Myoungsoo Kim 2 , Woo Chul Kim 1 , Hun Jung Kim 1

1 Inha university, Radiation onoclogy, Incheon, Korea, Republic of. 2 Incheon St Mary hospital, Radiation onoclogy, Incheon, Korea, Republic of

Purpose/Objective:

Stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FRT) has been increasingly administered as an initial treatment for patients affected by brain metastases (BM). We assessed clinical outcomes of SRS/FRT in a series of patients aged 65 years and older with 1-10 BM from non-small cell lung cancer (NSCLC).

Material/Methods:

We retrospectively reviewed 92 older NSCLC patients with 222 BM were treated with SRS/FSRT at bi-institution between 2010 and 2020. The end-point was overall survival (OS). Univariate and multivariate analyses were performed to define the prognostic factors related to OS. The in-field local control (IFLC) within the SRS/FSRT field was also evaluated.

Results:

During a median follow-up period of 14 months (range 2-104 months), the median overall survival (OS) was 32 months. The 1- and 2-year survival rates were 69.8 and 56.1 %, respectively. Both NSCLC-specific graded prognostic assessment (GPA) (p = 0.007) and systemic therapy (p = 0.039) were prognosticators affecting OS in the multivariate analysis. The median IFLC period was 31 months, and 1- and 2-year IFLC rates were 75.9 and 57.6 %, respectively. The total volume of BM (p = 0.042) appeared to be a significant feature of IFLC. No adverse events > grade 2 were reported during and after SRS/FSRT.

Conclusion: