ESTRO 2024 - Abstract Book

S762

Clinical - CNS

ESTRO 2024

Keywords: Staged SRS, brain metastases, fluciclovine PET

References:

- Angelov L, et al. Impact of 2- staged stereotactic radiosurgery for treatment of brain metastases ≥ 2 cm. J Neurosurg. 2018;129(2):366-82.

- Minniti G, et al. Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis. Int J Radiat Oncol Biol Phys. 2016;95(4):1142-8.

- Kotecha R, et al. Recent advances in managing brain metastasis. F1000Res. 2018;7

- Galldiks N, et al. Amino acid PET in neuro-oncology: applications in the clinic. Expert Rev Anticancer Ther. 2017;17(5):395-7.

567

Digital Poster

Cavity SRS in excised brain metastases: treatment characteristics & outcomes in a real-world cohort

Kelvin CM Cheung 1 , James CH Chow 1 , Gavin TC Cheung 2 , Kwok Hung Au 1

1 Queen Elizabeth Hospital, Clinical Oncology, Hong Kong, Hong Kong. 2 United Christian Hospital, Clinical Oncology, Hong Kong, Hong Kong

Purpose/Objective:

Brain metastases from solid tumours harbour significant morbidity and poor overall prognosis. Surgical excision has an important role in treatment of brain metastases. Stereotactic radiosurgery (SRS) to the resection cavity improves local control while preserving cognitive outcomes as compared to whole brain irradiation. We investigated outcomes of such treatment in a real-world cohort from two tertiary institutions.

Material/Methods:

All consecutive patients who received resection cavity SRS for brain metastases during 2018 - 2022 were identified from the institutional databases of two tertiary oncology centres. SRS was delivered via linear accelerator using a frameless system. Patients were followed up by regular magnetic resonance imaging (MRI). Clinical features, pathological characteristics and treatment details were summarized using descriptive statistics. Local control rate (LCR), distant brain control rate (DBCR), local relapse-free survival (LRFS), and overall survival (OS) were estimated