ESTRO 2024 - Abstract Book

S783

Clinical - CNS

ESTRO 2024

(n=142)

(n=90)

(n=38)

(n=14)

71.5 (56 – 84)

Age, years (range)

70 (34 – 87) 70 (34 – 87) 69.5(42 – 83)

Gender

Male

100

59

29

12

Female

42

31

9

2

KPS

0 – 60

35

29

6

0

70 – 80

37

29

8

0

70

32

24

14

90 – 100

Lung (NSCLC or NOS) Lung (Small cell)

Primary tumour site

55

36

19

0

47

27

6

14

Breast

9

7

2

0

Stomach

6

5

1

0

Colon

and

4

2

2

0

rectum

Others

21

13

8

0

Concurrent extra-cranial RT

No

139

88

37

14

Yes

3

2

1

0

Prior history of RT

None

86

62

21

3

Cranial

8

5

3

0

Extra-cranial 48

23

14

11

Prior RT courses

1 course

46

22

13

11

2 courses

7

3

4

0

3+ courses 3

3

0

0

Abbreviations: KPS, Karnofsky Performance Status; NSCLC, non-small cell lung cancer; NOS, not other specified; RT, Radiotherapy

The median (interquartile range [IQR]) of baseline TLC was 1325 (923 – 1799), 1298 (978 – 1524) and 1216 (800 – 1776) for WBRT, SRS/SRT and PCI, respectively. TLC in WBRT were 946 (626 – 1316), 992 (675 – 1291) and 1075 (762 – 1435) at 0 – 2 weeks, 2 – 4 weeks and 4 – 8 weeks after brain RT (Figure). In the WBRT courses, significant decreases in TLC were observed at all time points (p<0.001, p<0.001 and p=0.008, respectively). In the SRS/SRT courses, TLC were 1392 (992 – 1705, p=0.301), 1081 (823 – 1308, p=0.058) and 1268 (921 – 1552, p=0.792), respectively. The PCI courses showed no significant change in TLC at any time point with the median (IQR) of 1047 (752 – 1357, p=0.492), 1031 (673 – 1974, p=0.841) and 1170 (723 – 1624, p=0.542), respectively.