ESTRO 2024 - Abstract Book

S789

Clinical - CNS

ESTRO 2024

780

Digital Poster

Proton radiotherapy in meningioma and hemangiopericytoma: a monocentric clinical report

Lucia Pia Ciccone 1 , Giulia Riva 1 , Christina Amanda Goodyear 2 , Giulia Fontana 3 , Sithin Thulasi Seetha 3,4 , Silvia Molinelli 5 , Alessia Bazani 5 , Maria Bonora 1 , Sara Ronchi 1 , Amelia Barcellini 1 , Jessica Franzetti 1 , Anna Maria Camarda 1 , Marco Rotondi 1 , Agnieszka Chalaszczyk 1 , Rossana Ingargiola 1 , Sara Lillo 1 , Francesca Colombo 1 , Viviana Vitolo 1 , Maria Rosaria Fiore 1 , Barbara Vischioni 1 , Alberto Iannalfi 1 , Mario Ciocca 5 , Ester Orlandi 1 1 National Center for Oncological Hadrontherapy (CNAO), Radiation Oncology Unit, Clinical Department, Pavia, Italy. 2 Federico II School of Medicine, Department of Advanced Biomedical Sciences, Naples, Italy. 3 National Center for Oncological Hadrontherapy (CNAO), Clinical Department, Pavia, Italy. 4 University of Pavia, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Pavia, Italy. 5 National Center for Oncological Hadrontherapy (CNAO), Medical Physics Unit, Clinical Department, Pavia, Italy

Purpose/Objective:

Meningioma and hemangiopericytoma are intracranial extra-axial tumors with different cell origins but similar radiological characteristics. They may be located near critical organs. There are commonalities in radiotherapy management of these neoplasia (i.e. treatment volumes and dose distribution). Protons, thanks to their physical and radiobiological properties, can spare healthy tissue, decreasing the dose delivered to the non-target areas. So, proton radiotherapy (PT) is a promising treatment for these tumors. Herein we present a monocentric report of meningioma and hemangiopericytoma treated with PT. Moreover, we evaluate the incidence and clinical prognostic factors of PT-induced toxicity.

Material/Methods:

We reviewed data from 176 patients with intracranial tumor (167 meningiomas and 9 hemangiopericytomas) treated with PT from January 2014 to April 2023 and prospectively followed up. Reirradiation cases were excluded. PT was conventionally fractionated and delivered with a pencil beam- scanning technique. The patients’ characteristics are summarized in Image1.