ESTRO 2024 - Abstract Book

S808

Clinical - CNS

ESTRO 2024

Conclusion:

PBT is an effective treatment for meningioma with good feasibility and limited toxicities in the majority of patients. Local recurrence is the most common failure pattern highlighting the relevance of effective local treatment options for higher-grade (WHO grade II/III) and progressed meningiomas.

Keywords: meningioma, proton therapy, local control

References:

1. Holtzman AL, Glassman GE, Dagan R, et al. Long-term outcomes of fractionated proton beam therapy for benign or radiographic intracranial meningioma. J Neurooncol. 2023 Feb;161(3):481-489.

2. García-Marqueta M, Vázquez M, Krcek R, et al. Quality of Life, Clinical, and Patient-Reported Outcomes after Pencil Beam Scanning Proton Therapy Delivered for Intracranial Grade WHO 1-2 Meningioma in Children and Adolescents. Cancers (Basel). 2023 Sep 6;15(18):4447. 3. Flechl B, Konrath L, Hug E, et al. Meningioma WHO I with involvement of the optical structures-does proton therapy lead to changes in quality of life with regard to subjective visual performance? Strahlenther Onkol. 2023 Apr;199(4):404-411.

4. Bachtiary B, Veraguth D, Roos N, et al. Hearing Loss in Cancer Patients with Skull Base Tumors Undergoing Pencil Beam Scanning Proton Therapy: A Retrospective Cohort Study. Cancers (Basel). 2022 Aug 9;14(16):3853.

5. Florijn MA, Sharfo AWM, Wiggenraad RGJ, et al. Lower doses to hippocampi and other brain structures for skull base meningiomas with intensity modulated proton therapy compared to photon therapy. Radiother Oncol. 2020 Jan; 142:147-153.