ESTRO 2024 - Abstract Book

S816

Clinical - CNS

ESTRO 2024

Conclusion:

GTV D80 > 42 Gy in five fractions led to better volume reduction and local control. The goal of planning an inhomogeneous dose distribution for fSRS in brain metastases may be to increase the GTV D80 and GTV D98. Further studies on inhomogeneous dose distributions are required.

Keywords: brain metastases, inhomogeneous dose distribution

1044

Mini-Oral

Reappraising prognostic factors after SRS/FSRT of brain metastases in the era of targeted therapies

Christoph A Fink 1 , Bouchra Tawk 1 , Laura Hahnemann 1 , Petros Christopoulos 2 , Juliane Hörner-Rieber 1 , Fabian Weykamp 1 , Kristin Lang 1 , Michael Thomas 2 , Jürgen Debus 1 , Laila König 1 1 University Hospital Heidelberg, Radiation Oncology, Heidelberg, Germany. 2 Thoraxklinik, Department of Thoracic Oncology, Heidelberg, Germany

Purpose/Objective:

The number of brain metastases (BM) is an important prognostic factor of overall survival (OS) for cancer patients with BM and influences clinical treatment decision-making. However, with increasing life expectancy in the metastatic stage in the era of new systemic therapy options, reexamining whether the number of BM is still prognostic of OS after stereotactic radiotherapy (sRT) may be warranted. The aim of this present study is a