ESTRO 2024 - Abstract Book

S827

Clinical - CNS

ESTRO 2024

Figure 2: Hub regions: left/right superior parietal (yellow), left/right superior frontal (light blue), left/right precentral (green), left/right postcentral (dark blue), left/right putamen (blue), right thalamus (red) and left thalamus (orange).

Conclusion:

Glioma patients frequently exhibit cognitive impairment and display distinct alterations in network topology following oncological treatment compared to healthy controls. Our findings underscore the relevance of nodal metrics, particularly in hub regions, in understanding the cognitive consequences of glioma and its treatment. To further investigate the potential role of radiation-induced damage as an explanation for this hub-specific failure, we plan to co-register radiation dose maps with the connectome maps. This co-registration will allow us to explore possible dependencies between radiation dose and the observed alterations in hub-specific network features.

Keywords: Cognition, Toxicity, Glioma

References:

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