ESTRO 2024 - Abstract Book

S865

Clinical - CNS

ESTRO 2024

more than 343 cc was 13.2 months versus 9.9 months (p<0.01). The median PFS was 10.45 months (3.7-16.1) and a DSS of 12.9 months (3.3-37.2).

Conclusion:

Survival analysis of molecular glioblastoma shows poor outcomes in comparison to histological glioblastoma. A higher dose of radiotherapy correlates with superior survival in these patients. Longer follow-ups in prospective studies would help provide various other survival outcomes.

Keywords: molecular GBM, TERTp mutation, chemoradiation

References:

1. Louis DN, Perry A, Burger P, Ellison DW, Reifenberger G, von Deimling A, Aldape K, Brat D, Collins VP, Eberhart C, Figarella ‐ Branger D. I nternational S ociety of N europathology ‐ H aarlem C onsensus G uidelines for N ervous S ystem T umor C lassification and G rading. Brain pathology. 2014 Sep;24(5):429-35. 2. Lee D, Riestenberg RA, Haskell-Mendoza A, Bloch O. Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review. Journal of Neuro-Oncology. 2021 Mar;152:89-98. 3. Tesileanu CM, Dirven L, Wijnenga MM, Koekkoek JA, Vincent AJ, Dubbink HJ, Atmodimedjo PN, Kros JM, van Duinen SG, Smits M, Taphoorn MJ. Survival of diffuse astrocytic glioma, IDH1/2 wildtype, with molecular features of glioblastoma, WHO grade IV: a confirmation of the cIMPACT-NOW criteria. Neuro-oncology. 2020 Apr 15;22(4):515 23. 4. Louis DN, Perry A, Burger P, Ellison DW, Reifenberger G, von Deimling A, Aldape K, Brat D, Collins VP, Eberhart C, Figarella ‐ Branger D. I nternational S ociety of N europathology ‐ H aarlem C onsensus G uidelines for N ervous S ystem T umor C lassification and G rading. Brain pathology. 2014 Sep;24(5):429-35.

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Clinical outcomes and a new Prognostic Index in Stereotactic Radiotherapy for Brain Metastases

Marco Lucarelli 1,2 , Rosario Bonelli 1,2 , Marianna Trignani 1 , Marta Di Nicola 2 , Annamaria Porreca 2 , Domenico Genovesi 1,2 1 "SS Annunziata" Hospital, Radiation Oncology Unit, Chieti, Italy. 2 "G. d'Annunzio" University, Department of Medical, Oral and Biotechnologies Sciences, Chieti, Italy