ESTRO 2024 - Abstract Book

S887

Clinical - CNS

ESTRO 2024

Keywords: melanoma brain metastases, toxicity, SRS

References:

Lehrer EJ, Peterson J, Brown PD, Sheehan JP, Qui.ones-Hinojosa A, Zaorsky NG et al (2019) Treatment of brain metastases with stereotactic radiosurgery and immune checkpoint inhibitors: An international meta-analysis of individual patient data. Radiother Oncol 130:104 – 112

Weingarten N, Kruser TJ, Bloch O (2019) Symptomatic radiation necrosis in brain metastasis patients treated with stereotactic radiosurgery and immunotherapy. Clin Neurol Neurosurg 179:14 – 18

2080

Digital Poster

Impact of adjuvant radiotherapy in atypical and anaplastic meningioma

Isacco Desideri 1 , Daniela Greto 1 , Carlotta Becherini 1 , Luca Visani 1 , Carolina Orsatti 1 , Pietro Garlatti 1 , Emanuela Olmetto 1 , Doruntina Cela 1 , Niccolò Bertini 1 , Monica Mangoni 1 , Giulio Francolini 1 , Pierluigi Bonomo 1 , Filippo Nozzoli 2 , Anna Peruzzi 1 , Maria Grazia Carnevale 1 , Alessandro Della Puppa 3 , Lorenzo Livi 1 1 University of Florence, Radiation Oncology Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. 2 University of Florence, Pathology Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. 3 University of Florence, Neurosurgery Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy

Purpose/Objective:

Meningiomas account for approximately 30% of all primary intracranial tumors. Most meningiomas are benign; 20% are atypical WHO grade II; <5% are WHO grade III. The role of radiotherapy (RT) in the treatment of resected atypical meningiomas (AM) has been controversial, while there is general consensus that RT has always a beneficial role in the adjuvant setting of anaplastic meningioma (ANM). We sought to examine the role of RT for AM and ANM in the adjuvant setting at the University of Florence (Unifi).

Material/Methods:

Patients diagnosed with AM and ANM treated with RT or initial observation at Unifi from 2009-2022 were identified and retrospectively analyzed. Patients were graded and diagnosed utilizing the WHO 2021 grading system . Data on age, gender, clinical onset, surgical type, radiation dose and modality as well as a wide array of histological features (brain invasion, bone invasion, number of mitosis (/10HPF), proliferation index [ki-67], necrosis) were investigated. Estimates of disease-free survival (DFS) and overall survival (OS) were performed using the Kaplan Meier (K-M) method.