ESTRO 2024 - Abstract Book

S896

Clinical - CNS

ESTRO 2024

Conclusion:

In this analysis a contouring variability was observed, increasing in case of brain metastases with dural/venous sinus contact and infratentorial location; moreover, a disagreement was observed in the inclusion and the definition of surgical tract. The next step of current study is a nationwide webinar with the aim to promote the sharing of best standard care and to potentially improve equability and uniformity of the clinical practice. A further analysis is ongoing on the assessment of IOV post-webinar and the impact of educational event.

Keywords: Contouring, variability

2238

Proffered Paper

Efficacy and Safety of Low Dose Radiation Therapy for Alzheimer’s Disease: Phase II Clinical Trial

Weon Kuu Chung 1 , Doo Yeul Lee 1 , Woo-Yoon Park 2 , Byoung Hyuck Kim 3 , Eun-Hee Hong 4 , Hak Young Rhee 5 , Aryun Kim 6 , Keun You Kim 7 1 Kyung Hee University Hospital at Gangdong, Department of Radiaiton Oncology, Seoul, Korea, Republic of. 2 Chungbuk National University Hospital, Department of Radiaiton Oncology, Cheongju, Korea, Republic of. 3 Seoul Metropolitan Government Seoul national University Borame Medical Center, Department of Radiaiton Oncology, Seoul, Korea, Republic of. 4 Korea Hydro & Nuclear Power Co Ltd., Radiation Health Research Institute, Seoul, Korea, Republic of. 5 Kyung Hee University Hospital at Gangdong, Department of Neurology, Seoul, Korea, Republic of. 6 Chungbuk National University Hospital, Department of Neurology, Cheongju, Korea, Republic of. 7 Seoul Metropolitan Government Seoul national University Borame Medical Center, Department of Psychiatry, Seoul, Korea, Republic of

Purpose/Objective:

This study aims to investigate the efficacy and safety of whole-brain low-dose radiation therapy (LDRT) as a potential treatment for patients with mild Alzheimer’s Disease (AD) based on preclinical evidence, case reports, and a preliminary small pilot trial in humans.